Natural killer cell education in human health and disease

Jeanette E. Boudreau; Katharine C. Hsu

doi:10.1016/j.coi.2017.11.003

Natural killer cell education in human health and disease

Jeanette E. Boudreau, Katharine C. Hsu

Medicine

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

102 Citas (Scopus)

Resumen

Natural killer (NK) cells maintain immune homeostasis by detecting and eliminating damaged cells. Simultaneous activating and inhibitory input are integrated by NK cells, with the net signal prompting cytotoxicity and cytokine production, or inhibition. Chief among the inhibitory ligands for NK cells are ‘self’ human leukocyte antigen (HLA) molecules, which are sensed by killer immunoglobulin-like receptors (KIR). Through a process called ‘education’, the functional capabilities of each NK cell are counterbalanced by their sensitivity for inhibition by co-inherited ‘self’ HLA. HLA and their ligands, the killer immunoglobulin-like receptors (KIR), are encoded by polymorphic, polygenic gene loci that segregate independently, therefore, NK education and function differ even between related individuals. In this review, we describe how variation in NK education, reactivity and sensitivity for inhibition impacts reproductive success, infection, cancer, inflammatory and autoimmune diseases.

Idioma original	English
Páginas (desde-hasta)	102-111
Número de páginas	10
Publicación	Current Opinion in Immunology
Volumen	50
DOI	https://doi.org/10.1016/j.coi.2017.11.003
Estado	Published - feb. 2018

Nota bibliográfica

Funding Information:
The authors apologize to those researchers whose work could not be included in this review due to space restrictions. This review was supported by NIH grants AI125651, HL129472, CA23766, AI069197, AI123658, and funding from The Leukemia and Lymphoma Society and Alex's Lemonade Stand Foundation to KCH. This work was supported by a grant from the Banting Research Foundation, the Canadian Cancer Society and the Canadian Institutes of Health Research — Institute of Cancer Research (grant #705275) and The Beatrice Hunter Cancer Research Institute to JEB.

Funding Information:
The authors apologize to those researchers whose work could not be included in this review due to space restrictions. This review was supported by NIH grants AI125651 , HL129472 , CA23766 , AI069197 , AI123658 , and funding from The Leukemia and Lymphoma Society and Alex's Lemonade Stand Foundation to KCH. This work was supported by a grant from the Banting Research Foundation, the Canadian Cancer Society and the Canadian Institutes of Health Research — Institute of Cancer Research (grant # 705275 ) and The Beatrice Hunter Cancer Research Institute to JEB.

Publisher Copyright:
© 2017 Elsevier Ltd

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

ODS de las Naciones Unidas

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title = "Natural killer cell education in human health and disease",

abstract = "Natural killer (NK) cells maintain immune homeostasis by detecting and eliminating damaged cells. Simultaneous activating and inhibitory input are integrated by NK cells, with the net signal prompting cytotoxicity and cytokine production, or inhibition. Chief among the inhibitory ligands for NK cells are {\textquoteleft}self{\textquoteright} human leukocyte antigen (HLA) molecules, which are sensed by killer immunoglobulin-like receptors (KIR). Through a process called {\textquoteleft}education{\textquoteright}, the functional capabilities of each NK cell are counterbalanced by their sensitivity for inhibition by co-inherited {\textquoteleft}self{\textquoteright} HLA. HLA and their ligands, the killer immunoglobulin-like receptors (KIR), are encoded by polymorphic, polygenic gene loci that segregate independently, therefore, NK education and function differ even between related individuals. In this review, we describe how variation in NK education, reactivity and sensitivity for inhibition impacts reproductive success, infection, cancer, inflammatory and autoimmune diseases.",

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note = "Funding Information: The authors apologize to those researchers whose work could not be included in this review due to space restrictions. This review was supported by NIH grants AI125651, HL129472, CA23766, AI069197, AI123658, and funding from The Leukemia and Lymphoma Society and Alex's Lemonade Stand Foundation to KCH. This work was supported by a grant from the Banting Research Foundation, the Canadian Cancer Society and the Canadian Institutes of Health Research — Institute of Cancer Research (grant #705275) and The Beatrice Hunter Cancer Research Institute to JEB. Funding Information: The authors apologize to those researchers whose work could not be included in this review due to space restrictions. This review was supported by NIH grants AI125651 , HL129472 , CA23766 , AI069197 , AI123658 , and funding from The Leukemia and Lymphoma Society and Alex's Lemonade Stand Foundation to KCH. This work was supported by a grant from the Banting Research Foundation, the Canadian Cancer Society and the Canadian Institutes of Health Research — Institute of Cancer Research (grant # 705275 ) and The Beatrice Hunter Cancer Research Institute to JEB. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

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Natural killer cell education in human health and disease

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Nota bibliográfica

ASJC Scopus Subject Areas

ODS de las Naciones Unidas

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