Neonatal host defense mechanisms against listeria monocytogenes infection: The role of lipopolysaccharides and interferons

R. Bortolussi, T. Issekutz, S. Burbridge, H. Schellekens

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

18 Citas (Scopus)

Resumen

The human newborn infant is susceptible to lethal infection caused by a number of bacterial species including Listeria monocytogenes, a gram-positive rod which is pathogenic by virtue of its ability to survive intracellularly. In adult animals interferon (lFN)-α/β and IFN-γor agents that induce or augment IFN production confer protection against lethal L. monocytogenes infection. Regulation and production of IFN is poorly understood during the neonatal period. We therefore evaluated the role of lFN-a/β and IFN-γ, IFN-inducers (polyinosinic:poly-cytidylic acid, amino-bromo-phenyl-pyrimidinone, amino-iodophenyl pyrimidinone) and lipopolysaccharide in modifying neonatal L. monocytogenes infection. Pretreatment of juvenile rats with polyinosinic:polycytidylic acid or lipopolysaccharide protected them against a lethal challenge with L. monocytogenes. Among newborn rats, polyinosinic: polycytidylic acid, amino-iodo-phenyl pyrimidinone and amino-bromophenyl-pyrimidinone gave significant protection, however, lipopolysaccharide did not influence survival. The role of IFN was further examined. Pretreatment of 3-d-old rats with purified IFN-α/β, native rat IFN-γor rDNA rat IFN-γ protected them against the lethality of subsequent L. monocytogenes injection. At 3 d after bacterial challenge, bacterial content in the spleens of 3-d-old rats pretreated with rIFN-γwere significantly decreased compared to controls: IFN- α/β -pretreated animals had less of a decrease, which become significant only 5 d after challenge. Our experiments indicate a role for IFN in neonatal host defense against L. monocytogenes infection.

Idioma originalEnglish
Páginas (desde-hasta)311-315
Número de páginas5
PublicaciónPediatric Research
Volumen25
N.º3
DOI
EstadoPublished - mar. 1989

ASJC Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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