Norepinephrine reduces excitability of single cutaneous primary afferent C-fibers in the cat spinal cord

S. Jeftinija; K. Semba; M. Randić

doi:10.1016/0006-8993(81)90310-3

Norepinephrine reduces excitability of single cutaneous primary afferent C-fibers in the cat spinal cord

S. Jeftinija, K. Semba, M. Randić

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

33 Citas (Scopus)

Resumen

An excitability testing procedure of single afferent C-fibers was used to study possible presynaptic actions of norepinephrine (NE) applied locally at the intraspinal sites of minimal threshold for their antidromic activation in spinalized cats. NE, applied by iontophoresis and/or pressure microinjection, produced dose-related increases in threshold for antidromic activation in 44 of 65 C-fibers. It was concluded that in addition to previously shown postsynaptic depressant action, NE reduces excitability of intraspinal cutaneous C-fibers.

Idioma original	English
Páginas (desde-hasta)	456-463
Número de páginas	8
Publicación	Brain Research
Volumen	219
N.º	2
DOI	https://doi.org/10.1016/0006-8993(81)90310-3
Estado	Published - ago. 31 1981
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
We would like to thank Drs. D. Egger and H. Geller for their helpful comments on the manuscript. This work was supported by the National Science Foundation (BNS 23871) and the United States Department of Agriculture.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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abstract = "An excitability testing procedure of single afferent C-fibers was used to study possible presynaptic actions of norepinephrine (NE) applied locally at the intraspinal sites of minimal threshold for their antidromic activation in spinalized cats. NE, applied by iontophoresis and/or pressure microinjection, produced dose-related increases in threshold for antidromic activation in 44 of 65 C-fibers. It was concluded that in addition to previously shown postsynaptic depressant action, NE reduces excitability of intraspinal cutaneous C-fibers.",

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AU - Semba, K.

AU - Randić, M.

N1 - Funding Information: We would like to thank Drs. D. Egger and H. Geller for their helpful comments on the manuscript. This work was supported by the National Science Foundation (BNS 23871) and the United States Department of Agriculture.

PY - 1981/8/31

Y1 - 1981/8/31

N2 - An excitability testing procedure of single afferent C-fibers was used to study possible presynaptic actions of norepinephrine (NE) applied locally at the intraspinal sites of minimal threshold for their antidromic activation in spinalized cats. NE, applied by iontophoresis and/or pressure microinjection, produced dose-related increases in threshold for antidromic activation in 44 of 65 C-fibers. It was concluded that in addition to previously shown postsynaptic depressant action, NE reduces excitability of intraspinal cutaneous C-fibers.

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Norepinephrine reduces excitability of single cutaneous primary afferent C-fibers in the cat spinal cord

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

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