Ocular blood flow measured with scanning laser Doppler flowmeter in normals and glaucoma patients

M. T. Nicolela, P. Hnik, S. M. Drance

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Resumen

Purpose: To study the retinal and optic disc blood flow in normal subjects and in patients with primary open angle glaucoma (POAG). Methods: Ocular blood flow was measured in one eye of 32 POAG patients and of 25 controls of similar age with a scanning laser Doppler flowmeter (SLDF). This technique combines a laser Doppler flowmeter with a scanning laser system, generating a two-dimensional "perfusion map" of 2.7x0.7 mm (256 points × 64 lines, digital resolution of 10 μm). In this study we obtained images of the optic disc (rim and lamina cribrosa) and of the peripapillary retina. Blood flow, volume and velocity were measured at the same four points in the retina (2 temporal, 1 superior and 1 inferior), at one point in the optic disc rim and at one point in the lamina cribrosa. Results: POAG subjects had significantly lower flow and volume at one of the two temporal retinal points (p=0.05 and p=0.001 respectively); lower volume in the inferior retinal point (p=0.04); and lower flow, velocity and volume in the lamina cribrosa (p=0.05, p=0.05 and p=0.005 respectively) compared to normal controls. 59% of the glaucoma subjects and none of the controls were judged as having avascular areas in the lamina cribrosa (p<0.0001). Conclusions: The most striking differences between POAG patients and normal controls studied with SLDF occurred at the level of the lamina cribrosa, indicating a deficient blood flow in glaucoma patients at that location. Further studies should determine if these changes precede the glaucomatous damage or are secondary to it.

Idioma originalEnglish
Páginas (desde-hasta)S30
PublicaciónInvestigative Ophthalmology and Visual Science
Volumen37
N.º3
EstadoPublished - feb. 15 1996
Publicado de forma externa

ASJC Scopus Subject Areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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