Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria

Hongli Yang; Haomin Luo; Christy Hardin; Yaxing Wang; Jin Wook Jeoung; Cindy Albert; Jayme R. Vianna; Glen P. Sharpe; Juan Reynaud; Shaban Demirel; Steven L. Mansberger; Brad Fortune; Marcelo Nicolela; Stuart K. Gardiner; Balwantray C. Chauhan; Claude F. Burgoyne

doi:10.1016/j.ajo.2019.12.020

Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria

Hongli Yang, Haomin Luo, Christy Hardin, Yaxing Wang, Jin Wook Jeoung, Cindy Albert, Jayme R. Vianna, Glen P. Sharpe, Juan Reynaud, Shaban Demirel, Steven L. Mansberger, Brad Fortune, Marcelo Nicolela, Stuart K. Gardiner, Balwantray C. Chauhan, Claude F. Burgoyne

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

13 Citas (Scopus)

Resumen

Purpose: This study evaluated the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to detect optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. Design: Retrospective cross-sectional study. Methods: A total of 196 GL eyes, 150 GLS eyes, and 303 heathy eyes underwent pRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane, Bruch's membrane opening (BMO), and outer pRNFL segmentations. MRW and pRNFLT were quantified in 6 Garway-Heath or 12 30-degree (clock-hour) sectors. OCT abnormality for each parameter was defined to be less than the 5th percentile of the healthy eye distribution. OCT abnormality for individual eyes was defined using global, sectoral, and combined parameter criteria that achieved ≥95% specificity in the healthy eyes. TC combination criteria required the sectoral location of MRW and pRNFLT abnormality to be topographically aligned and included comMR (a previously reported TC combination consisting of MRW and pRNFLT parameter: [MRW + pRNFLT × (average MRW healthy eyes/average pRNFLT healthy eyes) MRW]. Results: TC sectoral criteria (1 Garway-Heath MRW + corresponding Garway-Heath RNFLT), (one 30-degree MRW + any 1 corresponding or adjacent 30-degree pRNFLT), 30-degree and Garway-Heath comMR-TI and global comMR were the best performing criteria, demonstrating (96%-99% specificity), 86%-91% sensitivity for GL, 80%-84% sensitivity for early GL (MD ≥ −4.0 dB) and 93%-96% sensitivity for moderate-to-advanced GL (MD < −4.0 dB). Conclusions: Clinically intuitive TC MRW and pRNFLT combination criteria identified the sectoral location of OCT abnormality in GL eyes with high diagnostic precision.

Idioma original	English
Páginas (desde-hasta)	203-216
Número de páginas	14
Publicación	American Journal of Ophthalmology
Volumen	213
DOI	https://doi.org/10.1016/j.ajo.2019.12.020
Estado	Published - may. 2020

Nota bibliográfica

Funding Information:
Funding/Support: This study was supported by US National Institutes of Health / National Eye Institute (NIH/NEI) grant R01-EY-019674 and R01-EY021281 (which funded manual segmentation, data generation, analysis and interpretation); by the Legacy Good Samaritan Foundation ; Canadian Institutes of Health Research ; Dalhousie Medical Research Foundation , Dalhousie, Nova Scotia, Canada; and Heidelberg Engineering, GmbH, Heidelberg, Germany. The sponsors and donors had no role in the design, conduct, analysis or reporting of this research.

Funding Information:
All authors have completed and submitted the ICMJE form for Disclosure of Potential Conflicts of Interest and none were reported. Funding/Support: This study was supported by US National Institutes of Health/National Eye Institute (NIH/NEI) grant R01-EY-019674 and R01-EY021281 (which funded manual segmentation, data generation, analysis and interpretation); by the Legacy Good Samaritan Foundation; Canadian Institutes of Health Research; Dalhousie Medical Research Foundation, Dalhousie, Nova Scotia, Canada; and Heidelberg Engineering, GmbH, Heidelberg, Germany. The sponsors and donors had no role in the design, conduct, analysis or reporting of this research. Financial Disclosures: Dr. Chauhan is a consultant for Allergan and Heidelberg Engineering; and is a lecturer for Allergan and Santen; and receives research support from CenterVue, Heidelberg Engineering, and Topcon. Dr. Burgoyne is a consultant for and receives research support from Heidelberg Engineering. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The authors thank the Japanese53 and Brazilian52 normative study investigators for allowing us to assess the specificity of the OCT structural abnormality criteria described herein in each cohort. The authors also thank Ping Wei, PhD, for help with data analysis and mark checking; Dionys Murphy, MDiv, and Luke Reyes, PhD (Candidate) for proof reading; and Amber Gunter for her assistance with manuscript preparation and submission.

Publisher Copyright:
© 2019 Elsevier Inc.

ASJC Scopus Subject Areas

Ophthalmology

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10.1016/j.ajo.2019.12.020

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Yang, H., Luo, H., Hardin, C., Wang, Y., Jeoung, J. W., Albert, C., Vianna, J. R., Sharpe, G. P., Reynaud, J., Demirel, S., Mansberger, S. L., Fortune, B., Nicolela, M., Gardiner, S. K., Chauhan, B. C., & Burgoyne, C. F. (2020). Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria. American Journal of Ophthalmology, 213, 203-216. https://doi.org/10.1016/j.ajo.2019.12.020

Yang, H, Luo, H, Hardin, C, Wang, Y, Jeoung, JW, Albert, C, Vianna, JR, Sharpe, GP, Reynaud, J, Demirel, S, Mansberger, SL, Fortune, B, Nicolela, M, Gardiner, SK, Chauhan, BC & Burgoyne, CF 2020, 'Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria', American Journal of Ophthalmology, vol. 213, pp. 203-216. https://doi.org/10.1016/j.ajo.2019.12.020

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title = "Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria",

abstract = "Purpose: This study evaluated the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to detect optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. Design: Retrospective cross-sectional study. Methods: A total of 196 GL eyes, 150 GLS eyes, and 303 heathy eyes underwent pRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane, Bruch's membrane opening (BMO), and outer pRNFL segmentations. MRW and pRNFLT were quantified in 6 Garway-Heath or 12 30-degree (clock-hour) sectors. OCT abnormality for each parameter was defined to be less than the 5th percentile of the healthy eye distribution. OCT abnormality for individual eyes was defined using global, sectoral, and combined parameter criteria that achieved ≥95% specificity in the healthy eyes. TC combination criteria required the sectoral location of MRW and pRNFLT abnormality to be topographically aligned and included comMR (a previously reported TC combination consisting of MRW and pRNFLT parameter: [MRW + pRNFLT × (average MRW healthy eyes/average pRNFLT healthy eyes) MRW]. Results: TC sectoral criteria (1 Garway-Heath MRW + corresponding Garway-Heath RNFLT), (one 30-degree MRW + any 1 corresponding or adjacent 30-degree pRNFLT), 30-degree and Garway-Heath comMR-TI and global comMR were the best performing criteria, demonstrating (96%-99% specificity), 86%-91% sensitivity for GL, 80%-84% sensitivity for early GL (MD ≥ −4.0 dB) and 93%-96% sensitivity for moderate-to-advanced GL (MD < −4.0 dB). Conclusions: Clinically intuitive TC MRW and pRNFLT combination criteria identified the sectoral location of OCT abnormality in GL eyes with high diagnostic precision.",

author = "Hongli Yang and Haomin Luo and Christy Hardin and Yaxing Wang and Jeoung, {Jin Wook} and Cindy Albert and Vianna, {Jayme R.} and Sharpe, {Glen P.} and Juan Reynaud and Shaban Demirel and Mansberger, {Steven L.} and Brad Fortune and Marcelo Nicolela and Gardiner, {Stuart K.} and Chauhan, {Balwantray C.} and Burgoyne, {Claude F.}",

note = "Funding Information: Funding/Support: This study was supported by US National Institutes of Health / National Eye Institute (NIH/NEI) grant R01-EY-019674 and R01-EY021281 (which funded manual segmentation, data generation, analysis and interpretation); by the Legacy Good Samaritan Foundation ; Canadian Institutes of Health Research ; Dalhousie Medical Research Foundation , Dalhousie, Nova Scotia, Canada; and Heidelberg Engineering, GmbH, Heidelberg, Germany. The sponsors and donors had no role in the design, conduct, analysis or reporting of this research. Funding Information: All authors have completed and submitted the ICMJE form for Disclosure of Potential Conflicts of Interest and none were reported. Funding/Support: This study was supported by US National Institutes of Health/National Eye Institute (NIH/NEI) grant R01-EY-019674 and R01-EY021281 (which funded manual segmentation, data generation, analysis and interpretation); by the Legacy Good Samaritan Foundation; Canadian Institutes of Health Research; Dalhousie Medical Research Foundation, Dalhousie, Nova Scotia, Canada; and Heidelberg Engineering, GmbH, Heidelberg, Germany. The sponsors and donors had no role in the design, conduct, analysis or reporting of this research. Financial Disclosures: Dr. Chauhan is a consultant for Allergan and Heidelberg Engineering; and is a lecturer for Allergan and Santen; and receives research support from CenterVue, Heidelberg Engineering, and Topcon. Dr. Burgoyne is a consultant for and receives research support from Heidelberg Engineering. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The authors thank the Japanese53 and Brazilian52 normative study investigators for allowing us to assess the specificity of the OCT structural abnormality criteria described herein in each cohort. The authors also thank Ping Wei, PhD, for help with data analysis and mark checking; Dionys Murphy, MDiv, and Luke Reyes, PhD (Candidate) for proof reading; and Amber Gunter for her assistance with manuscript preparation and submission. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2020",

month = may,

doi = "10.1016/j.ajo.2019.12.020",

language = "English",

volume = "213",

pages = "203--216",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

}

TY - JOUR

T1 - Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria

AU - Yang, Hongli

AU - Luo, Haomin

AU - Hardin, Christy

AU - Wang, Yaxing

AU - Jeoung, Jin Wook

AU - Albert, Cindy

AU - Vianna, Jayme R.

AU - Sharpe, Glen P.

AU - Reynaud, Juan

AU - Demirel, Shaban

AU - Mansberger, Steven L.

AU - Fortune, Brad

AU - Nicolela, Marcelo

AU - Gardiner, Stuart K.

AU - Chauhan, Balwantray C.

AU - Burgoyne, Claude F.

N1 - Funding Information: Funding/Support: This study was supported by US National Institutes of Health / National Eye Institute (NIH/NEI) grant R01-EY-019674 and R01-EY021281 (which funded manual segmentation, data generation, analysis and interpretation); by the Legacy Good Samaritan Foundation ; Canadian Institutes of Health Research ; Dalhousie Medical Research Foundation , Dalhousie, Nova Scotia, Canada; and Heidelberg Engineering, GmbH, Heidelberg, Germany. The sponsors and donors had no role in the design, conduct, analysis or reporting of this research. Funding Information: All authors have completed and submitted the ICMJE form for Disclosure of Potential Conflicts of Interest and none were reported. Funding/Support: This study was supported by US National Institutes of Health/National Eye Institute (NIH/NEI) grant R01-EY-019674 and R01-EY021281 (which funded manual segmentation, data generation, analysis and interpretation); by the Legacy Good Samaritan Foundation; Canadian Institutes of Health Research; Dalhousie Medical Research Foundation, Dalhousie, Nova Scotia, Canada; and Heidelberg Engineering, GmbH, Heidelberg, Germany. The sponsors and donors had no role in the design, conduct, analysis or reporting of this research. Financial Disclosures: Dr. Chauhan is a consultant for Allergan and Heidelberg Engineering; and is a lecturer for Allergan and Santen; and receives research support from CenterVue, Heidelberg Engineering, and Topcon. Dr. Burgoyne is a consultant for and receives research support from Heidelberg Engineering. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The authors thank the Japanese53 and Brazilian52 normative study investigators for allowing us to assess the specificity of the OCT structural abnormality criteria described herein in each cohort. The authors also thank Ping Wei, PhD, for help with data analysis and mark checking; Dionys Murphy, MDiv, and Luke Reyes, PhD (Candidate) for proof reading; and Amber Gunter for her assistance with manuscript preparation and submission. Publisher Copyright: © 2019 Elsevier Inc.

PY - 2020/5

Y1 - 2020/5

N2 - Purpose: This study evaluated the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to detect optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. Design: Retrospective cross-sectional study. Methods: A total of 196 GL eyes, 150 GLS eyes, and 303 heathy eyes underwent pRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane, Bruch's membrane opening (BMO), and outer pRNFL segmentations. MRW and pRNFLT were quantified in 6 Garway-Heath or 12 30-degree (clock-hour) sectors. OCT abnormality for each parameter was defined to be less than the 5th percentile of the healthy eye distribution. OCT abnormality for individual eyes was defined using global, sectoral, and combined parameter criteria that achieved ≥95% specificity in the healthy eyes. TC combination criteria required the sectoral location of MRW and pRNFLT abnormality to be topographically aligned and included comMR (a previously reported TC combination consisting of MRW and pRNFLT parameter: [MRW + pRNFLT × (average MRW healthy eyes/average pRNFLT healthy eyes) MRW]. Results: TC sectoral criteria (1 Garway-Heath MRW + corresponding Garway-Heath RNFLT), (one 30-degree MRW + any 1 corresponding or adjacent 30-degree pRNFLT), 30-degree and Garway-Heath comMR-TI and global comMR were the best performing criteria, demonstrating (96%-99% specificity), 86%-91% sensitivity for GL, 80%-84% sensitivity for early GL (MD ≥ −4.0 dB) and 93%-96% sensitivity for moderate-to-advanced GL (MD < −4.0 dB). Conclusions: Clinically intuitive TC MRW and pRNFLT combination criteria identified the sectoral location of OCT abnormality in GL eyes with high diagnostic precision.

AB - Purpose: This study evaluated the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to detect optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. Design: Retrospective cross-sectional study. Methods: A total of 196 GL eyes, 150 GLS eyes, and 303 heathy eyes underwent pRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane, Bruch's membrane opening (BMO), and outer pRNFL segmentations. MRW and pRNFLT were quantified in 6 Garway-Heath or 12 30-degree (clock-hour) sectors. OCT abnormality for each parameter was defined to be less than the 5th percentile of the healthy eye distribution. OCT abnormality for individual eyes was defined using global, sectoral, and combined parameter criteria that achieved ≥95% specificity in the healthy eyes. TC combination criteria required the sectoral location of MRW and pRNFLT abnormality to be topographically aligned and included comMR (a previously reported TC combination consisting of MRW and pRNFLT parameter: [MRW + pRNFLT × (average MRW healthy eyes/average pRNFLT healthy eyes) MRW]. Results: TC sectoral criteria (1 Garway-Heath MRW + corresponding Garway-Heath RNFLT), (one 30-degree MRW + any 1 corresponding or adjacent 30-degree pRNFLT), 30-degree and Garway-Heath comMR-TI and global comMR were the best performing criteria, demonstrating (96%-99% specificity), 86%-91% sensitivity for GL, 80%-84% sensitivity for early GL (MD ≥ −4.0 dB) and 93%-96% sensitivity for moderate-to-advanced GL (MD < −4.0 dB). Conclusions: Clinically intuitive TC MRW and pRNFLT combination criteria identified the sectoral location of OCT abnormality in GL eyes with high diagnostic precision.

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Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria

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