Optimized cell transplantation using adult rag2 mutant zebrafsh

Qin Tang, Nouran S. Abdelfattah, Jessica S. Blackburn, John C. Moore, Sarah A. Martinez, Finola E. Moore, Riadh Lobbardi, Inês M. Tenente, Myron S. Ignatius, Jason N. Berman, Robert S. Liwski, Yariv Houvras, David M. Langenau

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

115 Citas (Scopus)

Resumen

Cell transplantation into adult zebrafsh has lagged behind mouse models owing to the lack of immunocompromised strains. here we have created rag2E450fs mutant zebrafsh that have reduced numbers of functional t and b cells but are viable and fecund. mutant fsh engraft muscle, blood stem cells and various cancers. rag2E450fs mutant zebrafsh are the frst immunocompromised zebrafsh model that permits robust, long-term engraftment of multiple tissues and cancer.

Idioma originalEnglish
Páginas (desde-hasta)821-824
Número de páginas4
PublicaciónNature Methods
Volumen11
N.º8
DOI
EstadoPublished - ago. 2014

ASJC Scopus Subject Areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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