Optimized cell transplantation using adult rag2 mutant zebrafsh

Qin Tang; Nouran S. Abdelfattah; Jessica S. Blackburn; John C. Moore; Sarah A. Martinez; Finola E. Moore; Riadh Lobbardi; Inês M. Tenente; Myron S. Ignatius; Jason N. Berman; Robert S. Liwski; Yariv Houvras; David M. Langenau

doi:10.1038/nmeth.3031

Optimized cell transplantation using adult rag2 mutant zebrafsh

Qin Tang, Nouran S. Abdelfattah, Jessica S. Blackburn, John C. Moore, Sarah A. Martinez, Finola E. Moore, Riadh Lobbardi, Inês M. Tenente, Myron S. Ignatius, Jason N. Berman, Robert S. Liwski, Yariv Houvras, David M. Langenau

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

115 Citas (Scopus)

Resumen

Cell transplantation into adult zebrafsh has lagged behind mouse models owing to the lack of immunocompromised strains. here we have created rag2^E450fs mutant zebrafsh that have reduced numbers of functional t and b cells but are viable and fecund. mutant fsh engraft muscle, blood stem cells and various cancers. rag2^E450fs mutant zebrafsh are the frst immunocompromised zebrafsh model that permits robust, long-term engraftment of multiple tissues and cancer.

Idioma original	English
Páginas (desde-hasta)	821-824
Número de páginas	4
Publicación	Nature Methods
Volumen	11
N.º	8
DOI	https://doi.org/10.1038/nmeth.3031
Estado	Published - ago. 2014

ASJC Scopus Subject Areas

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

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title = "Optimized cell transplantation using adult rag2 mutant zebrafsh",

abstract = "Cell transplantation into adult zebrafsh has lagged behind mouse models owing to the lack of immunocompromised strains. here we have created rag2E450fs mutant zebrafsh that have reduced numbers of functional t and b cells but are viable and fecund. mutant fsh engraft muscle, blood stem cells and various cancers. rag2E450fs mutant zebrafsh are the frst immunocompromised zebrafsh model that permits robust, long-term engraftment of multiple tissues and cancer.",

author = "Qin Tang and Abdelfattah, {Nouran S.} and Blackburn, {Jessica S.} and Moore, {John C.} and Martinez, {Sarah A.} and Moore, {Finola E.} and Riadh Lobbardi and Tenente, {In{\^e}s M.} and Ignatius, {Myron S.} and Berman, {Jason N.} and Liwski, {Robert S.} and Yariv Houvras and Langenau, {David M.}",

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month = aug,

doi = "10.1038/nmeth.3031",

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T1 - Optimized cell transplantation using adult rag2 mutant zebrafsh

AU - Tang, Qin

AU - Abdelfattah, Nouran S.

AU - Blackburn, Jessica S.

AU - Moore, John C.

AU - Martinez, Sarah A.

AU - Moore, Finola E.

AU - Lobbardi, Riadh

AU - Tenente, Inês M.

AU - Ignatius, Myron S.

AU - Berman, Jason N.

AU - Liwski, Robert S.

AU - Houvras, Yariv

AU - Langenau, David M.

PY - 2014/8

Y1 - 2014/8

N2 - Cell transplantation into adult zebrafsh has lagged behind mouse models owing to the lack of immunocompromised strains. here we have created rag2E450fs mutant zebrafsh that have reduced numbers of functional t and b cells but are viable and fecund. mutant fsh engraft muscle, blood stem cells and various cancers. rag2E450fs mutant zebrafsh are the frst immunocompromised zebrafsh model that permits robust, long-term engraftment of multiple tissues and cancer.

AB - Cell transplantation into adult zebrafsh has lagged behind mouse models owing to the lack of immunocompromised strains. here we have created rag2E450fs mutant zebrafsh that have reduced numbers of functional t and b cells but are viable and fecund. mutant fsh engraft muscle, blood stem cells and various cancers. rag2E450fs mutant zebrafsh are the frst immunocompromised zebrafsh model that permits robust, long-term engraftment of multiple tissues and cancer.

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Optimized cell transplantation using adult rag2 mutant zebrafsh

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