Pivotal role of duct epithelia in salivary gland GVHD

Masaru Sasaki, Yasushi Sawanobori, Toshiya Tanaka, Hiashi Ueta, Yusuke Kitazawa, Sachiko Kikuta, Thomas B. Issekutz, Kenjiro Matsuno

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

1 Cita (Scopus)

Resumen

Although salivary glands are one of the target organs in graft-versus host disease (GVHD), mechanism of disease-related tissue injury has been poorly understood. To investigate it, we employed rat GVHD model including irradiation and donor cell transfer. Immunostaining revealed that submandibular and parotid, but not sublingual glands showed acinar reduction whereas ducts were almost intact. Ductal area of sublingual glands was significantly smaller than those of submandibular and parotid glands. Ductal epithelial cells upregulated expression of class II major histocompatibility complex antigens overtime. This expression preceded donor cell infiltration. Donor cell infiltration was preferentially found in ductal area at the early phase of the disease. While ductal epithelial cells exhibited upregulated mRNA expression of Th1-type chemokines, infiltrating donor cells exhibited their receptors CXCR3 and CCR5. These results suggest ductal epithelial cells have a pivotal role in the progression of GVHD.

Idioma originalEnglish
Páginas (desde-hasta)9-21
Número de páginas13
PublicaciónArchives of Histology and Cytology
Volumen76
N.º1
DOI
EstadoPublished - mar. 4 2016

Nota bibliográfica

Publisher Copyright:
© 2016 by International Society of Histology and Cytology.

ASJC Scopus Subject Areas

  • Histology

Huella

Profundice en los temas de investigación de 'Pivotal role of duct epithelia in salivary gland GVHD'. En conjunto forman una huella única.

Citar esto