Prenatal exposure to phthalates and male reproductive system development: Results from a Canadian pregnancy cohort study

Rodrigo L.P. Romao; Linda Dodds; Jillian Ashley-Martin; Patricia Monnier; Tye E. Arbuckle

doi:10.1016/j.reprotox.2020.04.078

Prenatal exposure to phthalates and male reproductive system development: Results from a Canadian pregnancy cohort study

Rodrigo L.P. Romao, Linda Dodds, Jillian Ashley-Martin, Patricia Monnier, Tye E. Arbuckle

Medicine

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

5 Citas (Scopus)

Resumen

Our objective was to determine if maternal first trimester urinary phthalate concentrations are associated with reduced penile length (PL) or width (PW) at birth in full term singletons. First trimester phthalate metabolite urinary concentrations were obtained from mothers participating in a Canadian pregnancy cohort study (MIREC). PL and PW were measured shortly after birth in the male offspring. Univariate and multivariable linear regressions were performed to study associations between maternal phthalate exposure and penile measurements, adjusting for confounders. On univariate analysis of 170 mother-infant pairs, PW showed an inverse relationship with the concentration of mono-3-carboxypropyl phthalate (MCPP-p = 0.016), which was not confirmed on multivariable analysis. On multivariable analysis controlling for infant's size and other confounders, no statistically signficant associations between phthalate metabolite concentrations and PL or PW were identified. In this population of Canadian women, there was no strong evidence to suggest an association between maternal first trimester urinary phthalates with PL or PW in term singletons.

Idioma original	English
Páginas (desde-hasta)	11-18
Número de páginas	8
Publicación	Reproductive Toxicology
Volumen	95
DOI	https://doi.org/10.1016/j.reprotox.2020.04.078
Estado	Published - ago. 2020

Nota bibliográfica

Funding Information:
The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (grant # MOP - 81285) and the Ontario Ministry of the Environment. The MIREC-ID Study was funded by Health Canada's Chemicals Management Plan.

Funding Information:
Male infants delivered by mothers participating in the Maternal-Infant Research on Environmental Chemicals Infant Development cohort (MIREC-ID) were assessed at birth. Details about the design of the MIREC Research Platform have been published elsewhere [ 22 ]. In summary, 1983 healthy pregnant women from 10 Canadian cities were recruited to participate from 2008 to 2011. Eligibility criteria included ability to communicate in English or French, age > 18 years, gestational age < 14 weeks. Ethics approval was obtained from Health Canada and participating sites. Women with significant medical conditions or carrying fetuses with major abnormalities were excluded. The study received funding from the Canadian Institute for Health Research and Health Canada.

Funding Information:
The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (grant # MOP - 81285) and the Ontario Ministry of the Environment. The MIREC-ID Study was funded by Health Canada's Chemicals Management Plan.

Publisher Copyright:
© 2020

ASJC Scopus Subject Areas

Toxicology

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10.1016/j.reprotox.2020.04.078

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@article{375f653bab2344fe80292a3272d909dc,

title = "Prenatal exposure to phthalates and male reproductive system development: Results from a Canadian pregnancy cohort study",

abstract = "Our objective was to determine if maternal first trimester urinary phthalate concentrations are associated with reduced penile length (PL) or width (PW) at birth in full term singletons. First trimester phthalate metabolite urinary concentrations were obtained from mothers participating in a Canadian pregnancy cohort study (MIREC). PL and PW were measured shortly after birth in the male offspring. Univariate and multivariable linear regressions were performed to study associations between maternal phthalate exposure and penile measurements, adjusting for confounders. On univariate analysis of 170 mother-infant pairs, PW showed an inverse relationship with the concentration of mono-3-carboxypropyl phthalate (MCPP-p = 0.016), which was not confirmed on multivariable analysis. On multivariable analysis controlling for infant's size and other confounders, no statistically signficant associations between phthalate metabolite concentrations and PL or PW were identified. In this population of Canadian women, there was no strong evidence to suggest an association between maternal first trimester urinary phthalates with PL or PW in term singletons.",

author = "Romao, {Rodrigo L.P.} and Linda Dodds and Jillian Ashley-Martin and Patricia Monnier and Arbuckle, {Tye E.}",

note = "Funding Information: The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (grant # MOP - 81285) and the Ontario Ministry of the Environment. The MIREC-ID Study was funded by Health Canada's Chemicals Management Plan. Funding Information: Male infants delivered by mothers participating in the Maternal-Infant Research on Environmental Chemicals Infant Development cohort (MIREC-ID) were assessed at birth. Details about the design of the MIREC Research Platform have been published elsewhere [ 22 ]. In summary, 1983 healthy pregnant women from 10 Canadian cities were recruited to participate from 2008 to 2011. Eligibility criteria included ability to communicate in English or French, age > 18 years, gestational age < 14 weeks. Ethics approval was obtained from Health Canada and participating sites. Women with significant medical conditions or carrying fetuses with major abnormalities were excluded. The study received funding from the Canadian Institute for Health Research and Health Canada. Funding Information: The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (grant # MOP - 81285) and the Ontario Ministry of the Environment. The MIREC-ID Study was funded by Health Canada's Chemicals Management Plan. Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = aug,

doi = "10.1016/j.reprotox.2020.04.078",

language = "English",

volume = "95",

pages = "11--18",

journal = "Reproductive Toxicology",

issn = "0890-6238",

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T1 - Prenatal exposure to phthalates and male reproductive system development

T2 - Results from a Canadian pregnancy cohort study

AU - Romao, Rodrigo L.P.

AU - Dodds, Linda

AU - Ashley-Martin, Jillian

AU - Monnier, Patricia

AU - Arbuckle, Tye E.

N1 - Funding Information: The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (grant # MOP - 81285) and the Ontario Ministry of the Environment. The MIREC-ID Study was funded by Health Canada's Chemicals Management Plan. Funding Information: Male infants delivered by mothers participating in the Maternal-Infant Research on Environmental Chemicals Infant Development cohort (MIREC-ID) were assessed at birth. Details about the design of the MIREC Research Platform have been published elsewhere [ 22 ]. In summary, 1983 healthy pregnant women from 10 Canadian cities were recruited to participate from 2008 to 2011. Eligibility criteria included ability to communicate in English or French, age > 18 years, gestational age < 14 weeks. Ethics approval was obtained from Health Canada and participating sites. Women with significant medical conditions or carrying fetuses with major abnormalities were excluded. The study received funding from the Canadian Institute for Health Research and Health Canada. Funding Information: The MIREC Study was funded by Health Canada's Chemicals Management Plan, the Canadian Institute of Health Research (grant # MOP - 81285) and the Ontario Ministry of the Environment. The MIREC-ID Study was funded by Health Canada's Chemicals Management Plan. Publisher Copyright: © 2020

PY - 2020/8

Y1 - 2020/8

N2 - Our objective was to determine if maternal first trimester urinary phthalate concentrations are associated with reduced penile length (PL) or width (PW) at birth in full term singletons. First trimester phthalate metabolite urinary concentrations were obtained from mothers participating in a Canadian pregnancy cohort study (MIREC). PL and PW were measured shortly after birth in the male offspring. Univariate and multivariable linear regressions were performed to study associations between maternal phthalate exposure and penile measurements, adjusting for confounders. On univariate analysis of 170 mother-infant pairs, PW showed an inverse relationship with the concentration of mono-3-carboxypropyl phthalate (MCPP-p = 0.016), which was not confirmed on multivariable analysis. On multivariable analysis controlling for infant's size and other confounders, no statistically signficant associations between phthalate metabolite concentrations and PL or PW were identified. In this population of Canadian women, there was no strong evidence to suggest an association between maternal first trimester urinary phthalates with PL or PW in term singletons.

AB - Our objective was to determine if maternal first trimester urinary phthalate concentrations are associated with reduced penile length (PL) or width (PW) at birth in full term singletons. First trimester phthalate metabolite urinary concentrations were obtained from mothers participating in a Canadian pregnancy cohort study (MIREC). PL and PW were measured shortly after birth in the male offspring. Univariate and multivariable linear regressions were performed to study associations between maternal phthalate exposure and penile measurements, adjusting for confounders. On univariate analysis of 170 mother-infant pairs, PW showed an inverse relationship with the concentration of mono-3-carboxypropyl phthalate (MCPP-p = 0.016), which was not confirmed on multivariable analysis. On multivariable analysis controlling for infant's size and other confounders, no statistically signficant associations between phthalate metabolite concentrations and PL or PW were identified. In this population of Canadian women, there was no strong evidence to suggest an association between maternal first trimester urinary phthalates with PL or PW in term singletons.

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SN - 0890-6238

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JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Prenatal exposure to phthalates and male reproductive system development: Results from a Canadian pregnancy cohort study

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

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