Resumen
The fetal time period is a critical window of immune system development and resulting heightened susceptibility to the adverse effects of environmental exposures. Epidemiologists and toxicologists have hypothesized that phthalates, bisphenol A (BPA) and perfluoroalkyl substance have immunotoxic properties. Immunotoxic effects of chemicals may manifest in an altered immune system profile at birth. Immunoglobulin E, thymic stromal lymphopoietin (TSLP), and interleukin-33 (IL-33) are integral in the etiology of childhood allergy and detectable at birth. The objective of this study was to determine the association between maternal levels of phthalates, bisphenol A (BPA), and perfluoroalkyl substances and elevated umbilical cord blood levels of IgE, TSLP, and IL-33. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Of these women, 1258 had a singleton, term birth and cord blood sample. A Bayesian hierarchical model was employed to determine associations between log-transformed continuous variables and immune system biomarkers while adjusting for potential confounding from correlated environmental contaminants. Inverse, nonlinear associations were observed between maternal urinary MCPP levels and elevated levels of both IL-33/TSLP and IgE and between maternal urinary BPA levels and elevated levels of IL-33/TSLP. In this primarily urban Canadian population of pregnant women and their newborns, maternal urinary and plasma concentrations of phthalate metabolites, BPA, and perfluoroalkyl substances were not associated with immunotoxic effects that manifest as increased odds of elevated levels of IgE, TSLP or IL-33.
Idioma original | English |
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Páginas (desde-hasta) | 360-368 |
Número de páginas | 9 |
Publicación | Environmental Research |
Volumen | 140 |
DOI | |
Estado | Published - jul. 1 2015 |
Nota bibliográfica
Funding Information:We would like to acknowledge the valuable contributions of Yisong Wei, Nong Xu (and other members of the Marshall lab) for their assistance in the analysis of the cord blood samples. We would also like to acknowledge the MIREC biobank committee for granting access to the cord blood samples as well as the MIREC study participants for their dedication. This work was funded by a Category A Grant (Grant #10012 ) from the Izaak Walton Killam (IWK) Health Centre . The MIREC study was funded by the Chemicals Management Plan of Health Canada , the Canadian Institutes for Health Research (Grant #MOP – 81285 ), and the Ontario Ministry of the Environment .
Funding Information:
This work was funded by the Izaak Walton Killam (IWK) Health Centre. The MIREC study was funded by Health Canada, the Canadian Institutes for Health Research (CIHR) and the Ontario Ministry of the Environment.
Publisher Copyright:
© 2015.
ASJC Scopus Subject Areas
- Biochemistry
- General Environmental Science