TY - JOUR
T1 - Progression of impairment in patients with vascular cognitive impairment without dementia
AU - Wentzel, C.
AU - Rockwood, Kenneth
AU - MacKnight, C.
AU - Hachinski, V.
AU - Hogan, D. B.
AU - Feldman, H.
AU - Østbye, T.
AU - Wolfson, C.
AU - Gauthier, S.
AU - Verreault, R.
AU - McDowell, I.
PY - 2001/8/28
Y1 - 2001/8/28
N2 - Little is known about progression, short of dementia, in vascular cognitive impairment. In the Canadian Study of Health and Aging, 149 participants (79.3 ± 6.7 years; 61% women) were found to have vascular cognitive impairment, no dementia (CIND). After 5 years, 77 participants (52%) had died and 58 (46%) had developed dementia. Women were at greater risk of dementia (OR 2.1, 1.0 to 4.5). Of 32 participants alive without dementia, cognition had deteriorated in seven and improved in four. Half of those with vascular CIND developed dementia within 5 years, suggesting a target for preventive interventions.
AB - Little is known about progression, short of dementia, in vascular cognitive impairment. In the Canadian Study of Health and Aging, 149 participants (79.3 ± 6.7 years; 61% women) were found to have vascular cognitive impairment, no dementia (CIND). After 5 years, 77 participants (52%) had died and 58 (46%) had developed dementia. Women were at greater risk of dementia (OR 2.1, 1.0 to 4.5). Of 32 participants alive without dementia, cognition had deteriorated in seven and improved in four. Half of those with vascular CIND developed dementia within 5 years, suggesting a target for preventive interventions.
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U2 - 10.1212/WNL.57.4.714
DO - 10.1212/WNL.57.4.714
M3 - Article
C2 - 11524488
AN - SCOPUS:0035964244
SN - 0028-3878
VL - 57
SP - 714
EP - 716
JO - Neurology
JF - Neurology
IS - 4
ER -