TY - JOUR
T1 - Protection by salvianolic acid A against adriamycin toxicity on rat heart mitochondria
AU - Lin, Tong Jun
AU - Liu, Geng Tao
AU - Liu, Yang
AU - Xu, Guang Zhi
PY - 1992
Y1 - 1992
N2 - It was found that salvianolic acid A (Sai A) has potent antioxidant activity. The effects of Sai A on adriamycin-induced heart mitochondrial toxicity of rats in vitro and on adriamycin antitumor activity are investigated in this article. Malondialdehyde (MDA) formation and membrane rigidification of rat heart mitochondria intoxicated with adriamycin were significantly reduced by Sai A. In the electron spin resonance (ESR) studies, Sai A has no significant effect on the formation of adriamycin semiquinone radicals (AQ{dot operator}), while hydroxyl radicals generated by electron transfer from AQ{dot operator} to H2O2 were scavenged by Sai A dose-dependently. On the other hand, Sai A was shown to have no effects on the antitumor activity of adriamycin in cultured L1210 ascitic tumor cells and in mice with P388 ascite tumor. These results indicate that Sai A protects against adriamycin induced heart mitochondrial toxicity of rats, while Sai A has no antagonizing effect on the antitumor activity of adriamycin.
AB - It was found that salvianolic acid A (Sai A) has potent antioxidant activity. The effects of Sai A on adriamycin-induced heart mitochondrial toxicity of rats in vitro and on adriamycin antitumor activity are investigated in this article. Malondialdehyde (MDA) formation and membrane rigidification of rat heart mitochondria intoxicated with adriamycin were significantly reduced by Sai A. In the electron spin resonance (ESR) studies, Sai A has no significant effect on the formation of adriamycin semiquinone radicals (AQ{dot operator}), while hydroxyl radicals generated by electron transfer from AQ{dot operator} to H2O2 were scavenged by Sai A dose-dependently. On the other hand, Sai A was shown to have no effects on the antitumor activity of adriamycin in cultured L1210 ascitic tumor cells and in mice with P388 ascite tumor. These results indicate that Sai A protects against adriamycin induced heart mitochondrial toxicity of rats, while Sai A has no antagonizing effect on the antitumor activity of adriamycin.
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U2 - 10.1016/0891-5849(92)90083-S
DO - 10.1016/0891-5849(92)90083-S
M3 - Article
C2 - 1317322
AN - SCOPUS:0026511884
SN - 0891-5849
VL - 12
SP - 347
EP - 351
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 5
ER -