TY - JOUR
T1 - Protection by schisanhenol against adriamycin toxicity in rat heart mitochondria
AU - Tong-jun, Lin
AU - Geng-tao, Liu
AU - Yan, Pan
AU - Yang, Liu
AU - Guang Zhi Xu, Zhi Xu
PY - 1991/10/9
Y1 - 1991/10/9
N2 - The effects of schisanhenol (Sal) on Adriamycin® (ADM)-induced rat heart mitochondrial toxicity in vitro were investigated. Malondialdehyde formation, lysis, disintegration and membrane rigidification in mitochondria treated with ADM were reduced significantly by Sal. In the electron spin resonance studies, Sal did not affect significantly the formation of ADM semiquinone radicals (AQ'), whereas hydroxyl radicals generated by electron transfer from AQ to H2O2 were scavenged by Sal dose dependently. These results indicate that Sal could protect against ADM-induced rat heart mitochondrial toxicity.
AB - The effects of schisanhenol (Sal) on Adriamycin® (ADM)-induced rat heart mitochondrial toxicity in vitro were investigated. Malondialdehyde formation, lysis, disintegration and membrane rigidification in mitochondria treated with ADM were reduced significantly by Sal. In the electron spin resonance studies, Sal did not affect significantly the formation of ADM semiquinone radicals (AQ'), whereas hydroxyl radicals generated by electron transfer from AQ to H2O2 were scavenged by Sal dose dependently. These results indicate that Sal could protect against ADM-induced rat heart mitochondrial toxicity.
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U2 - 10.1016/0006-2952(91)90519-B
DO - 10.1016/0006-2952(91)90519-B
M3 - Article
C2 - 1657000
AN - SCOPUS:0025991682
SN - 0006-2952
VL - 42
SP - 1805
EP - 1810
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 9
ER -