Protocol for the PREHAB study - Pre-operative Rehabilitation for reduction of Hospitalization after coronary Bypass and valvular surgery: A randomised controlled trial

Andrew N. Stammers, D. Scott Kehler, Jonathan Afilalo, Lorraine J. Avery, Sean M. Bagshaw, Hilary P. Grocott, Jean Francois Légaré, Sarvesh Logsetty, Colleen Metge, Thang Nguyen, Kenneth Rockwood, Jitender Sareen, Jo Ann Sawatzky, Navdeep Tangri, Nicholas Giacomantonio, Ansar Hassan, Todd A. Duhamel, Rakesh C. Arora

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88 Citas (Scopus)

Resumen

Introduction: Frailty is a geriatric syndrome characterised by reductions in muscle mass, strength, endurance and activity level. The frailty syndrome, prevalent in 25-50% of patients undergoing cardiac surgery, is associated with increased rates of mortality and major morbidity as well as function decline postoperatively. This trial will compare a preoperative, interdisciplinary exercise and health promotion intervention to current standard of care (StanC) for elective coronary artery bypass and valvular surgery patients for the purpose of determining if the intervention improves 3-month and 12-month clinical outcomes among a population of frail patients waiting for elective cardiac surgery. Methods and analysis: This is a multicentre, randomised, open end point, controlled trial using assessor blinding and intent-to-treat analysis. Two-hundred and forty-four elective cardiac surgical patients will be recruited and randomised to receive either StanC or StanC plus an 8-week exercise and education intervention at a certified medical fitness facility. Patients will attend two weekly sessions and aerobic exercise will be prescribed at 40-60% of heart rate reserve. Data collection will occur at baseline, 1-2 weeks preoperatively, and at 3 and 12 months postoperatively. The primary outcome of the trial will be the proportion of patients requiring a hospital length of stay greater than 7 days. Potential impact of study: The healthcare team is faced with an increasingly complex older adult patient population. As such, this trial aims to provide novel evidence supporting a health intervention to ensure that frail, older adult patients thrive after undergoing cardiac surgery. Ethics and dissemination: Trial results will be published in peer-reviewed journals, and presented at national and international scientific meetings. The University of Manitoba Health Research Ethics Board has approved the study protocol V.1.3, dated 11 August 2014 (H2014:208). Trial registration number: The trial has been registered on ClinicalTrials.gov, a registry and results database of privately and publicly funded clinical studies (NCT02219815).

Idioma originalEnglish
Número de artículoe007250
PublicaciónBMJ Open
Volumen5
N.º3
DOI
EstadoPublished - 2015

Nota bibliográfica

Publisher Copyright:
© 2015, BMJ Publishing Group. All rights reserved.

ASJC Scopus Subject Areas

  • General Medicine

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