Sensory deafferentation fails to modify muscarinic receptor binding in raccoon somatosensory cortex

S. M. Sampson, C. Shaw, M. Wilkinson, D. D. Rasmusson

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5 Citas (Scopus)

Resumen

The characteristics and distribution of muscarinic acetylcholine (mACh) receptor binding in primary somatosensory (SI) cortex and the caudate nucleus of raccoons were studied using [3H]-QNB, a muscarinic antagonist. The binding characteristics were similar to reported values in rat and cat. Autoradiographs produced from tissue sections labeled with [3H]-QNB showed the distribution of mACh receptors in the forebrain of the raccoon. [3H]-QNB binding was highest in cerebral cortex, neostriatum and hippocampus. Within SI cortex, binding was high in layers I-III and VI and relatively low in layers IV and V. Autoradiographs obtained from animals that had undergone peripheral deafferentation of part of the forepaw revealed no changes in [3H]-QNB binding in the affected cortical region during the time that physiological reorganization is known to occur.

Idioma originalEnglish
Páginas (desde-hasta)597-601
Número de páginas5
PublicaciónBrain Research Bulletin
Volumen20
N.º5
DOI
EstadoPublished - may. 1988

ASJC Scopus Subject Areas

  • General Neuroscience

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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