TY - JOUR
T1 - Serotonin depletion after prolonged chlorpromazine treatment in a simpler model system
AU - Croll, Roger P.
AU - Baker, Michael W.
AU - Khabarova, Marina
AU - Voronezhskaya, Elena E.
AU - Sakharov, D. A.
PY - 1997/7
Y1 - 1997/7
N2 - 1. Prolonged exposure of the pond snail Lymnaea stagnalis to micromolar concentrations of chlorpromazine (CPZ) results in marked changes in the serotonin (5-HT) content of the central nervous system. 2. High-performance liquid chromatography with electrochemical detection indicates that levels of 5 HT, but not those of dihydroxyphenyl alanine (DOPA), dopamine or norepinephrine, were significantly decreased (e.g., to less than 40% of normal after 30 days of exposure to 1 μM CPZ in the bathing water). 3. Glyoxylate-induced fluorescence was depressed to undetectable levels in central, serotonergic neurons. 4. Performance of 5 HT-dependent motor behaviors was impaired. 5. The present results, in accord with earlier studies on the effects of chronic exposure to haloperidol, suggest that previously overlooked mechanisms of monoamine downregulation may contribute to long-term effects of antipsychotic drugs.
AB - 1. Prolonged exposure of the pond snail Lymnaea stagnalis to micromolar concentrations of chlorpromazine (CPZ) results in marked changes in the serotonin (5-HT) content of the central nervous system. 2. High-performance liquid chromatography with electrochemical detection indicates that levels of 5 HT, but not those of dihydroxyphenyl alanine (DOPA), dopamine or norepinephrine, were significantly decreased (e.g., to less than 40% of normal after 30 days of exposure to 1 μM CPZ in the bathing water). 3. Glyoxylate-induced fluorescence was depressed to undetectable levels in central, serotonergic neurons. 4. Performance of 5 HT-dependent motor behaviors was impaired. 5. The present results, in accord with earlier studies on the effects of chronic exposure to haloperidol, suggest that previously overlooked mechanisms of monoamine downregulation may contribute to long-term effects of antipsychotic drugs.
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U2 - 10.1016/S0306-3623(96)00530-7
DO - 10.1016/S0306-3623(96)00530-7
M3 - Article
AN - SCOPUS:0030977639
SN - 0306-3623
VL - 29
SP - 91
EP - 96
JO - Vascular Pharmacology
JF - Vascular Pharmacology
IS - 1
ER -