Severe, persistent, and fatal T-cell immunodeficiency following therapy for infantile leukemia

Ashley V. Geerlinks, Thomas Issekutz, Justin T. Wahlstrom, Kathleen E. Sullivan, Morton J. Cowan, Christopher C. Dvorak, Conrad V. Fernandez

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

12 Citas (Scopus)

Resumen

We describe five cases of children who completed chemotherapy for infantile acute lymphoblastic leukemia (ALL) and soon after were diagnosed with severe T-cell, non-HIV immunodeficiency, with varying B-cell and NK-cell depletion. There was near absence of CD3+, CD4+, and CD8+ cells. All patients developed multiple, primarily opportunistic infections. Unfortunately, four patients died, although one was successfully treated by hematopoietic stem cell transplantation. These immunodeficiencies appeared to be secondary to intensive infant ALL chemotherapy. Our report highlights the importance of the early consideration of this life-threatening immune complication in patients who received chemotherapy for infantile ALL.

Idioma originalEnglish
Páginas (desde-hasta)2046-2049
Número de páginas4
PublicaciónPediatric Blood and Cancer
Volumen63
N.º11
DOI
EstadoPublished - nov. 1 2016

Nota bibliográfica

Publisher Copyright:
© 2016 Wiley Periodicals, Inc.

ASJC Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

PubMed: MeSH publication types

  • Case Reports
  • Journal Article

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