Resumen
We describe five cases of children who completed chemotherapy for infantile acute lymphoblastic leukemia (ALL) and soon after were diagnosed with severe T-cell, non-HIV immunodeficiency, with varying B-cell and NK-cell depletion. There was near absence of CD3+, CD4+, and CD8+ cells. All patients developed multiple, primarily opportunistic infections. Unfortunately, four patients died, although one was successfully treated by hematopoietic stem cell transplantation. These immunodeficiencies appeared to be secondary to intensive infant ALL chemotherapy. Our report highlights the importance of the early consideration of this life-threatening immune complication in patients who received chemotherapy for infantile ALL.
Idioma original | English |
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Páginas (desde-hasta) | 2046-2049 |
Número de páginas | 4 |
Publicación | Pediatric Blood and Cancer |
Volumen | 63 |
N.º | 11 |
DOI | |
Estado | Published - nov. 1 2016 |
Nota bibliográfica
Publisher Copyright:© 2016 Wiley Periodicals, Inc.
ASJC Scopus Subject Areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology
PubMed: MeSH publication types
- Case Reports
- Journal Article