Somatosensory evoked potentials as indicators of altered cerebral excitability during psychotropic drug treatment

Hans Först; Andrea Zagorski; Bernd Pohlmann-Eden

doi:10.1016/0006-3223(91)90226-C

Somatosensory evoked potentials as indicators of altered cerebral excitability during psychotropic drug treatment

Hans Först, Andrea Zagorski, Bernd Pohlmann-Eden

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

4 Citas (Scopus)

Resumen

We observed an increase in the amplitude of the early cortical somatosensory evoked potentials (SSEPs) in five patients who developed myoclonus and/or generalized seizures during treatment with antidepressants. The increases correlated closely with the course of the clinical disturbances. In every case the SSEPs returned to normal values after the discontinuation of the psychotropic drugs. We suggest that SSEPs might help to identify and monitor patients who are at an increased risk of potentially hazardous side effects during psychopharmacological treatment.

Idioma original	English
Páginas (desde-hasta)	397-402
Número de páginas	6
Publicación	Biological Psychiatry
Volumen	29
N.º	4
DOI	https://doi.org/10.1016/0006-3223(91)90226-C
Estado	Published - feb. 15 1991
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
The help of B. Beats, W.F. Gattaz, and A. Rothenberger is gratefully acknowledged. The preparation of the manuscript was supported by a grant from the Deutsche Forschungsgemehaschaft to H.F.

ASJC Scopus Subject Areas

Biological Psychiatry

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10.1016/0006-3223(91)90226-C

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title = "Somatosensory evoked potentials as indicators of altered cerebral excitability during psychotropic drug treatment",

abstract = "We observed an increase in the amplitude of the early cortical somatosensory evoked potentials (SSEPs) in five patients who developed myoclonus and/or generalized seizures during treatment with antidepressants. The increases correlated closely with the course of the clinical disturbances. In every case the SSEPs returned to normal values after the discontinuation of the psychotropic drugs. We suggest that SSEPs might help to identify and monitor patients who are at an increased risk of potentially hazardous side effects during psychopharmacological treatment.",

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note = "Funding Information: The help of B. Beats, W.F. Gattaz, and A. Rothenberger is gratefully acknowledged. The preparation of the manuscript was supported by a grant from the Deutsche Forschungsgemehaschaft to H.F.",

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T1 - Somatosensory evoked potentials as indicators of altered cerebral excitability during psychotropic drug treatment

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AU - Zagorski, Andrea

AU - Pohlmann-Eden, Bernd

N1 - Funding Information: The help of B. Beats, W.F. Gattaz, and A. Rothenberger is gratefully acknowledged. The preparation of the manuscript was supported by a grant from the Deutsche Forschungsgemehaschaft to H.F.

PY - 1991/2/15

Y1 - 1991/2/15

N2 - We observed an increase in the amplitude of the early cortical somatosensory evoked potentials (SSEPs) in five patients who developed myoclonus and/or generalized seizures during treatment with antidepressants. The increases correlated closely with the course of the clinical disturbances. In every case the SSEPs returned to normal values after the discontinuation of the psychotropic drugs. We suggest that SSEPs might help to identify and monitor patients who are at an increased risk of potentially hazardous side effects during psychopharmacological treatment.

AB - We observed an increase in the amplitude of the early cortical somatosensory evoked potentials (SSEPs) in five patients who developed myoclonus and/or generalized seizures during treatment with antidepressants. The increases correlated closely with the course of the clinical disturbances. In every case the SSEPs returned to normal values after the discontinuation of the psychotropic drugs. We suggest that SSEPs might help to identify and monitor patients who are at an increased risk of potentially hazardous side effects during psychopharmacological treatment.

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JO - Biological Psychiatry

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Somatosensory evoked potentials as indicators of altered cerebral excitability during psychotropic drug treatment

Resumen

Nota bibliográfica

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