Stimulation of neutral, magnesium-stimulated sphingomyelinase activity in the neurohypophysis of the rat by hypertonic saline ingestion

N. C. Guy; J. T.R. Clarke; M. W. Spence; H. W. Cook

doi:10.1016/0361-9230(83)90028-X

Stimulation of neutral, magnesium-stimulated sphingomyelinase activity in the neurohypophysis of the rat by hypertonic saline ingestion

N. C. Guy, J. T.R. Clarke, M. W. Spence, H. W. Cook

Medicine

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

3 Citas (Scopus)

Resumen

Neutral, magnesium-stimulated Sphingomyelinase and acid Sphingomyelinase activities in the neurohypophysis, adenohypophysis and cerebrum of rats given 2.25% NaCI drinking water for 7 or 14 days were compared with the same enzyme activities in the tissues of control animals allowed free access to distilled drinking water. Neutral Sphingomyelinase activity in the neurohypophysis was significantly increased in both experimental groups (7-day, 85.2±8.4 units/mg protein; 14-day, 110.1±14.8units/mg; control, 61.4±5.5 units/mg). Acid Sphingomyelinase activity was significantly but only transiently increased in the tissue (7-day, 73.2±3.4 units/mg; 14-day, 66.3±7.5units/mg; control, 54.3±2.8 units). Enzyme activities in adenohypophysis and cerebrum of the experimental animals were not significantly different from those of controls. The results suggest a specific role for neutral, Mg²⁺-stimulated sphinomyelinase in neurosecretion.

Idioma original	English
Páginas (desde-hasta)	603-606
Número de páginas	4
Publicación	Brain Research Bulletin
Volumen	10
N.º	5
DOI	https://doi.org/10.1016/0361-9230(83)90028-X
Estado	Published - may. 1983

Nota bibliográfica

Funding Information:
This work was supported in part by a grant from the Medical Research Council of Canada (PG-16). N.C.G. was supported by a Studentshifpr om the Natural Sciencesa nd EngineeringR esearch Council of Canada; M.W.S. is a Career Investigator of the Medical Research Council of Canada.

ASJC Scopus Subject Areas

General Neuroscience

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title = "Stimulation of neutral, magnesium-stimulated sphingomyelinase activity in the neurohypophysis of the rat by hypertonic saline ingestion",

abstract = "Neutral, magnesium-stimulated Sphingomyelinase and acid Sphingomyelinase activities in the neurohypophysis, adenohypophysis and cerebrum of rats given 2.25% NaCI drinking water for 7 or 14 days were compared with the same enzyme activities in the tissues of control animals allowed free access to distilled drinking water. Neutral Sphingomyelinase activity in the neurohypophysis was significantly increased in both experimental groups (7-day, 85.2±8.4 units/mg protein; 14-day, 110.1±14.8units/mg; control, 61.4±5.5 units/mg). Acid Sphingomyelinase activity was significantly but only transiently increased in the tissue (7-day, 73.2±3.4 units/mg; 14-day, 66.3±7.5units/mg; control, 54.3±2.8 units). Enzyme activities in adenohypophysis and cerebrum of the experimental animals were not significantly different from those of controls. The results suggest a specific role for neutral, Mg2+-stimulated sphinomyelinase in neurosecretion.",

author = "Guy, {N. C.} and Clarke, {J. T.R.} and Spence, {M. W.} and Cook, {H. W.}",

note = "Funding Information: This work was supported in part by a grant from the Medical Research Council of Canada (PG-16). N.C.G. was supported by a Studentshifpr om the Natural Sciencesa nd EngineeringR esearch Council of Canada; M.W.S. is a Career Investigator of the Medical Research Council of Canada.",

year = "1983",

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doi = "10.1016/0361-9230(83)90028-X",

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AU - Guy, N. C.

AU - Clarke, J. T.R.

AU - Spence, M. W.

AU - Cook, H. W.

N1 - Funding Information: This work was supported in part by a grant from the Medical Research Council of Canada (PG-16). N.C.G. was supported by a Studentshifpr om the Natural Sciencesa nd EngineeringR esearch Council of Canada; M.W.S. is a Career Investigator of the Medical Research Council of Canada.

PY - 1983/5

Y1 - 1983/5

N2 - Neutral, magnesium-stimulated Sphingomyelinase and acid Sphingomyelinase activities in the neurohypophysis, adenohypophysis and cerebrum of rats given 2.25% NaCI drinking water for 7 or 14 days were compared with the same enzyme activities in the tissues of control animals allowed free access to distilled drinking water. Neutral Sphingomyelinase activity in the neurohypophysis was significantly increased in both experimental groups (7-day, 85.2±8.4 units/mg protein; 14-day, 110.1±14.8units/mg; control, 61.4±5.5 units/mg). Acid Sphingomyelinase activity was significantly but only transiently increased in the tissue (7-day, 73.2±3.4 units/mg; 14-day, 66.3±7.5units/mg; control, 54.3±2.8 units). Enzyme activities in adenohypophysis and cerebrum of the experimental animals were not significantly different from those of controls. The results suggest a specific role for neutral, Mg2+-stimulated sphinomyelinase in neurosecretion.

AB - Neutral, magnesium-stimulated Sphingomyelinase and acid Sphingomyelinase activities in the neurohypophysis, adenohypophysis and cerebrum of rats given 2.25% NaCI drinking water for 7 or 14 days were compared with the same enzyme activities in the tissues of control animals allowed free access to distilled drinking water. Neutral Sphingomyelinase activity in the neurohypophysis was significantly increased in both experimental groups (7-day, 85.2±8.4 units/mg protein; 14-day, 110.1±14.8units/mg; control, 61.4±5.5 units/mg). Acid Sphingomyelinase activity was significantly but only transiently increased in the tissue (7-day, 73.2±3.4 units/mg; 14-day, 66.3±7.5units/mg; control, 54.3±2.8 units). Enzyme activities in adenohypophysis and cerebrum of the experimental animals were not significantly different from those of controls. The results suggest a specific role for neutral, Mg2+-stimulated sphinomyelinase in neurosecretion.

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Stimulation of neutral, magnesium-stimulated sphingomyelinase activity in the neurohypophysis of the rat by hypertonic saline ingestion

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ASJC Scopus Subject Areas

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