Resumen
The successive acylation of glycerol-3-phosphate (G3P) by glycerol-3-phosphate acyltransferases and acylglycerol-3-phosphate acyltransferases produces phosphatidic acid (PA), a precursor for CDP-diacylglycerol-dependent phospholipid synthesis. PA is further dephosphorylated by LIPINs to produce diacylglycerol (DG), a substrate for the synthesis of triglyceride (TG) by DG acyltransferases and a precursor for phospholipid synthesis via the CDP-choline and CDP–ethanolamine (Kennedy) pathways. The channeling of fatty acids into TG for storage in lipid droplets and secretion in lipoproteins or phospholipids for membrane biogenesis is dependent on isoform expression, activity and localization of G3P pathway enzymes, as well as dietary and hormonal and tissue-specific factors. Here, we review the mechanisms that control partitioning of substrates into lipid products of the G3P pathway.
| Idioma original | English |
|---|---|
| Número de artículo | 158438 |
| Publicación | Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids |
| Volumen | 1865 |
| N.º | 1 |
| DOI | |
| Estado | Published - ene. 2020 |
Nota bibliográfica
Funding Information:This work was supported by an operating grant from the Canadian Institutes of Health Research ( MOP-136809 ). JL was the recipient of a Scotia Scholars Award.
Publisher Copyright:
© 2019 Elsevier B.V.
ASJC Scopus Subject Areas
- Molecular Biology
- Cell Biology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review