TY - JOUR
T1 - Tamoxifen in Malignant Melanoma
AU - Nesbit, Richard A.
AU - Woods, Robert L.
AU - Tattersall, Martin H.N.
AU - Fox, Richard M.
AU - Forbes, John F.
AU - Mackay, Ian R.
AU - Goodyear, M.
PY - 1979/11/29
Y1 - 1979/11/29
N2 - To the Editor: In the issue of July 5, Lerner et al. reported a possible adverse effect of oral contraceptives on the course of malignant melanoma. However, estrogens have been used to treat patients with malignant melanoma.1 We have treated 26 patients with advanced malignant melanoma with the antiestrogen tamoxifen, 20 to 40 mg per day. There were five women (four postmenopausal and one premenopausal) and 21 men. Five patients had received previous immunotherapy (BCG vaccine) and three had received previous chemotherapy. The dominant site of disease was soft tissue in 15 patients, viscera in nine patients, and bone and.
AB - To the Editor: In the issue of July 5, Lerner et al. reported a possible adverse effect of oral contraceptives on the course of malignant melanoma. However, estrogens have been used to treat patients with malignant melanoma.1 We have treated 26 patients with advanced malignant melanoma with the antiestrogen tamoxifen, 20 to 40 mg per day. There were five women (four postmenopausal and one premenopausal) and 21 men. Five patients had received previous immunotherapy (BCG vaccine) and three had received previous chemotherapy. The dominant site of disease was soft tissue in 15 patients, viscera in nine patients, and bone and.
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U2 - 10.1056/NEJM197911293012218
DO - 10.1056/NEJM197911293012218
M3 - Letter
C2 - 503125
AN - SCOPUS:0018602550
SN - 0028-4793
VL - 301
SP - 1241
EP - 1242
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 22
ER -