TY - JOUR
T1 - The comprehensive assessment of neurodegeneration and dementia
T2 - Canadian cohort study
AU - Chertkow, Howard
AU - Borrie, Michael
AU - Whitehead, Victor
AU - Black, Sandra E.
AU - Feldman, Howard H.
AU - Gauthier, Serge
AU - Hogan, David B.
AU - Masellis, Mario
AU - McGilton, Katherine
AU - Rockwood, Kenneth
AU - Tierney, Mary C.
AU - Andrew, Melissa
AU - Hsiung, Ging Yuek R.
AU - Camicioli, Richard
AU - Smith, Eric E.
AU - Fogarty, Jennifer
AU - Lindsay, Joseph
AU - Best, Sarah
AU - Evans, Alan
AU - Das, Samir
AU - Mohaddes, Zia
AU - Pilon, Randi
AU - Poirier, Judes
AU - Phillips, Natalie A.
AU - MacNamara, Elizabeth
AU - Dixon, Roger A.
AU - Duchesne, Simon
AU - MacKenzie, Ian
AU - Rylett, R. Jane
N1 - Funding Information:
The COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.
Publisher Copyright:
© 2019 The Canadian Journal of Neurological Sciences Inc.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Background: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams.Methods: The COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.Results: The CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020.Conclusion: Availability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years.
AB - Background: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams.Methods: The COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.Results: The CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020.Conclusion: Availability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years.
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U2 - 10.1017/cjn.2019.27
DO - 10.1017/cjn.2019.27
M3 - Article
C2 - 31309917
AN - SCOPUS:85071898719
SN - 0317-1671
VL - 46
SP - 499
EP - 511
JO - Canadian Journal of Neurological Sciences
JF - Canadian Journal of Neurological Sciences
IS - 5
ER -