The current landscape of NKT cell immunotherapy and the hills ahead

Adam Nelson; Jordan D. Lukacs; Brent Johnston

doi:10.3390/cancers13205174

The current landscape of NKT cell immunotherapy and the hills ahead

Adam Nelson, Jordan D. Lukacs, Brent Johnston

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

73 Citas (Scopus)

Resumen

NKT cells are a specialized subset of lipid-reactive T lymphocytes that play direct and indirect roles in immunosurveillance and anti-tumor immunity. Preclinical studies have shown that NKT cell activation via delivery of exogenous glycolipids elicits a significant anti-tumor immune response. Furthermore, infiltration of NKT cells is associated with a good prognosis in several cancers. In this review, we aim to summarize the role of NKT cells in cancer as well as the current strategies and status of NKT cell immunotherapy. This review also examines challenges and future directions for improving the therapy.

Idioma original	English
Número de artículo	5174
Publicación	Cancers
Volumen	13
N.º	20
DOI	https://doi.org/10.3390/cancers13205174
Estado	Published - oct. 1 2021

Nota bibliográfica

Funding Information:
Project was Funded by a CIHR operating grant (PJT-153285). A.N. is a trainee of the Beatrice Hunter Cancer Research Institute funded by Terry Fox Research Institute and Craig’s Cause Pancreatic Society. J.L is a trainee of the Beatrice Hunter Cancer Research Institute funded by CIBC. A.N. and J.L. hold I3V studentships funded by the Dalhousie Medical Research Foundation.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

Oncology
Cancer Research

PubMed: MeSH publication types

Journal Article
Review

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The current landscape of NKT cell immunotherapy and the hills ahead

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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