The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells

Medicine & Life Sciences

• 4-hydroxycyclophosphamide 10%
• Apoptosis 37%
• Aurora Kinase B 8%
• benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 8%
• Breast Cancer 3 8%
• Breast Neoplasms 7%
• Caspase 8 6%
• Caspase 9 6%
• Caspase Inhibitors 6%
• Cell Cycle 4%
• Cell Cycle Checkpoints 60%
• Cell Division 10%
• Cisplatin 5%
• Cyclophosphamide 5%
• Estrogen Receptors 5%
• fisetin 100%
• Flavonoids 62%
• Fluorouracil 5%
• Fruit 5%
• G2 Phase 6%
• Growth 8%
• Histones 5%
• human ERBB2 protein 6%
• Mitochondrial Membranes 6%
• Neoplasms 1%
• Pharmaceutical Preparations 25%
• Phosphorylation 3%
• Poly (ADP-Ribose) Polymerase-1 7%
• Serine 5%
• Therapeutics 0%
• Triple Negative Breast Neoplasms 74%
• Vegetables 5%

Chemical Compounds

• 4-Hydroxycyclophosphamide 13%
• 5-Fluorouracil 9%
• Antineoplastic Agent 54%
• Aurora 12%
• Bioactivity 5%
• Cisplatin 8%
• Cleavage 5%
• Cyclophosphamide 10%
• Estrogen 8%
• Fisetin 96%
• Flavonoid 58%
• Histone 8%
• Metabolite 5%
• Poly(ADPribose) 10%
• Serine 7%
• Z-VAD-FMK 16%