The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain

Chiara Mencarelli, Caroline Hammels, Joost Van Den Broeck, Mario Losen, Hellen Steinbusch, Francisco Revert, Juan Saus, David A. Hopkins, Marc H. De Baets, Harry W. Steinbusch, Pilar Martinez-Martinez

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

10 Citas (Scopus)

Resumen

The Goodpasture antigen-binding protein (GPBP) plays a critical role in brain development. Knockdown of GPBP leads to loss of myelinated tracts in the central nervous system and to extensive apoptosis in the brain during early embryogenesis. GPBP was initially identified as a protein associated with the autoantigen in Goodpasture autoimmune syndrome, where it was shown to be a kinase that regulates type IV collagen organization. GPBP isoforms bind and transport ceramide from the endoplasmic reticulum to the Golgi apparatus and are therefore also known as ceramide transporters (CERT). Ceramide dysregulation is involved in autoimmunity and neurodegenerative disorders. In order to analyze the possible role of GPBP in neuroinflammation and neurodegeneration we studied the basal GPBP expression in normal rat brain. High levels of immunoreactivity were detected in neurons of the cerebral cortex, hippocampal formation, the basal ganglia, the olfactory bulb and nuclei of the thalamus, the hypothalamus and the septal area. Lower expression levels of GPBP were observed widely throughout the brain, suggesting that GPBP plays an important role in central nervous system neuron function.

Idioma originalEnglish
Páginas (desde-hasta)97-105
Número de páginas9
PublicaciónJournal of Chemical Neuroanatomy
Volumen38
N.º2
DOI
EstadoPublished - oct. 2009

Nota bibliográfica

Funding Information:
We are very grateful to Marianne Markerink and Santiago Sampedro Millares for their excellent technical assistance. Juan Saus and Francisco Revert were supported by a SAF2006-12520-C02-01 grant from the Plan Nacional I+D+I from the Ministerio de Ciencia e Innovación.

ASJC Scopus Subject Areas

  • Cellular and Molecular Neuroscience

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