The functional significance behind expressing two IL-8 receptor types on PMN

Rose Marie Stillie, Shukkur Muhammed Farooq, John R. Gordon, Andrew W. Stadnyk

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239 Citas (Scopus)

Resumen

PMN are critical to innate immunity and are fundamental to antibacterial defense. To localize to sites of infection, PMN possess receptors that detect chemoattractant stimuli elicited at the site, such as chemokines, complement split products, or bioactive lipids. Signaling through these receptors stimulates chemotaxis toward the site of infection but also activates a number of biochemical processes, with the result that PMN kill invading bacteria. PMN possess two receptors, CXCR1 and CXCR2, for the N-terminal ELR motif-containing CXC chemokines, although only two chemokine members bind both receptors and the remainder binding only CXCR2. This peculiar pattern in receptor specificity has drawn considerable interest and investigation into whether signaling through each receptor might impart unique properties on the PMN. Indeed, at first glance, CXCR1 and CXCR2 appear to be functionally redundant; however, there are differences. Considering these proinflammatory activities of activating PMN through chemokine receptors, there has been great interest in the possibility that blocking CXCR1 and CXCR2 on PMN will provide a therapeutic benefit. The literature examining CXCR1 and CXCR2 in PMN function during human and modeled diseases will be reviewed, asking whether the functional differences can be perceived based on alterations in the role PMN play in these processes.

Idioma originalEnglish
Páginas (desde-hasta)529-543
Número de páginas15
PublicaciónJournal of Leukocyte Biology
Volumen86
N.º3
DOI
EstadoPublished - sep. 1 2009

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

PubMed: MeSH publication types

  • Journal Article
  • Review

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