The human tumor microbiome is composed of tumor type-specific intracellular bacteria

Deborah Nejman; Ilana Livyatan; Garold Fuks; Nancy Gavert; Yaara Zwang; Leore T. Geller; Aviva Rotter-Maskowitz; Roi Weiser; Giuseppe Mallel; Elinor Gigi; Arnon Meltser; Gavin M. Douglas; Iris Kamer; Vancheswaran Gopalakrishnan; Tali Dadosh; Smadar Levin-Zaidman; Sofia Avnet; Tehila Atlan; Zachary A. Cooper; Reetakshi Arora; Alexandria P. Cogdill; Md Abdul Wadud Khan; Gabriel Ologun; Yuval Bussi; Adina Weinberger; Maya Lotan-Pompan; Ofra Golani; Gili Perry; Merav Rokah; Keren Bahar-Shany; Elisa A. Rozeman; Christian U. Blank; Anat Ronai; Ron Shaoul; Amnon Amit; Tatiana Dorfman; Ran Kremer; Zvi R. Cohen; Sagi Harnof; Tali Siegal; Einav Yehuda-Shnaidman; Einav Nili Gal-Yam; Hagit Shapira; Nicola Baldini; Morgan G.I. Langille; Alon Ben-Nun; Bella Kaufman; Aviram Nissan; Talia Golan; Maya Dadiani; Keren Levanon; Jair Bar; Shlomit Katz Yust; Iris Barshack; Daniel S. Peeper; Dan J. Raz; Eran Segal; Jennifer A. Wargo; Judith Sandbank; Noam Shental; Ravid Straussman

doi:10.1126/science.aay9189

The human tumor microbiome is composed of tumor type-specific intracellular bacteria

Deborah Nejman, Ilana Livyatan, Garold Fuks, Nancy Gavert, Yaara Zwang, Leore T. Geller, Aviva Rotter-Maskowitz, Roi Weiser, Giuseppe Mallel, Elinor Gigi, Arnon Meltser, Gavin M. Douglas, Iris Kamer, Vancheswaran Gopalakrishnan, Tali Dadosh, Smadar Levin-Zaidman, Sofia Avnet, Tehila Atlan, Zachary A. Cooper, Reetakshi AroraAlexandria P. Cogdill, Md Abdul Wadud Khan, Gabriel Ologun, Yuval Bussi, Adina Weinberger, Maya Lotan-Pompan, Ofra Golani, Gili Perry, Merav Rokah, Keren Bahar-Shany, Elisa A. Rozeman, Christian U. Blank, Anat Ronai, Ron Shaoul, Amnon Amit, Tatiana Dorfman, Ran Kremer, Zvi R. Cohen, Sagi Harnof, Tali Siegal, Einav Yehuda-Shnaidman, Einav Nili Gal-Yam, Hagit Shapira, Nicola Baldini, Morgan G.I. Langille, Alon Ben-Nun, Bella Kaufman, Aviram Nissan, Talia Golan, Maya Dadiani, Keren Levanon, Jair Bar, Shlomit Katz Yust, Iris Barshack, Daniel S. Peeper, Dan J. Raz, Eran Segal, Jennifer A. Wargo, Judith Sandbank, Noam Shental, Ravid Straussman

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

1505 Citas (Scopus)

Resumen

Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.

Idioma original	English
Páginas (desde-hasta)	973-980
Número de páginas	8
Publicación	Science
Volumen	368
N.º	6494
DOI	https://doi.org/10.1126/science.aay9189
Estado	Published - may. 29 2020

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© 2020 American Association for the Advancement of Science. All rights reserved.

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General

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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Nejman, D., Livyatan, I., Fuks, G., Gavert, N., Zwang, Y., Geller, L. T., Rotter-Maskowitz, A., Weiser, R., Mallel, G., Gigi, E., Meltser, A., Douglas, G. M., Kamer, I., Gopalakrishnan, V., Dadosh, T., Levin-Zaidman, S., Avnet, S., Atlan, T., Cooper, Z. A., ... Straussman, R. (2020). The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science, 368(6494), 973-980. https://doi.org/10.1126/science.aay9189

Nejman, D, Livyatan, I, Fuks, G, Gavert, N, Zwang, Y, Geller, LT, Rotter-Maskowitz, A, Weiser, R, Mallel, G, Gigi, E, Meltser, A, Douglas, GM, Kamer, I, Gopalakrishnan, V, Dadosh, T, Levin-Zaidman, S, Avnet, S, Atlan, T, Cooper, ZA, Arora, R, Cogdill, AP, Khan, MAW, Ologun, G, Bussi, Y, Weinberger, A, Lotan-Pompan, M, Golani, O, Perry, G, Rokah, M, Bahar-Shany, K, Rozeman, EA, Blank, CU, Ronai, A, Shaoul, R, Amit, A, Dorfman, T, Kremer, R, Cohen, ZR, Harnof, S, Siegal, T, Yehuda-Shnaidman, E, Gal-Yam, EN, Shapira, H, Baldini, N, Langille, MGI, Ben-Nun, A, Kaufman, B, Nissan, A, Golan, T, Dadiani, M, Levanon, K, Bar, J, Yust, SK, Barshack, I, Peeper, DS, Raz, DJ, Segal, E, Wargo, JA, Sandbank, J, Shental, N & Straussman, R 2020, 'The human tumor microbiome is composed of tumor type-specific intracellular bacteria', Science, vol. 368, n.º 6494, pp. 973-980. https://doi.org/10.1126/science.aay9189

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title = "The human tumor microbiome is composed of tumor type-specific intracellular bacteria",

abstract = "Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.",

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AU - Nejman, Deborah

AU - Livyatan, Ilana

AU - Fuks, Garold

AU - Gavert, Nancy

AU - Zwang, Yaara

AU - Geller, Leore T.

AU - Rotter-Maskowitz, Aviva

AU - Weiser, Roi

AU - Mallel, Giuseppe

AU - Gigi, Elinor

AU - Meltser, Arnon

AU - Douglas, Gavin M.

AU - Kamer, Iris

AU - Gopalakrishnan, Vancheswaran

AU - Dadosh, Tali

AU - Levin-Zaidman, Smadar

AU - Avnet, Sofia

AU - Atlan, Tehila

AU - Cooper, Zachary A.

AU - Arora, Reetakshi

AU - Cogdill, Alexandria P.

AU - Khan, Md Abdul Wadud

AU - Ologun, Gabriel

AU - Bussi, Yuval

AU - Weinberger, Adina

AU - Lotan-Pompan, Maya

AU - Golani, Ofra

AU - Perry, Gili

AU - Rokah, Merav

AU - Bahar-Shany, Keren

AU - Rozeman, Elisa A.

AU - Blank, Christian U.

AU - Ronai, Anat

AU - Shaoul, Ron

AU - Amit, Amnon

AU - Dorfman, Tatiana

AU - Kremer, Ran

AU - Cohen, Zvi R.

AU - Harnof, Sagi

AU - Siegal, Tali

AU - Yehuda-Shnaidman, Einav

AU - Gal-Yam, Einav Nili

AU - Shapira, Hagit

AU - Baldini, Nicola

AU - Langille, Morgan G.I.

AU - Ben-Nun, Alon

AU - Kaufman, Bella

AU - Nissan, Aviram

AU - Golan, Talia

AU - Dadiani, Maya

AU - Levanon, Keren

AU - Bar, Jair

AU - Yust, Shlomit Katz

AU - Barshack, Iris

AU - Peeper, Daniel S.

AU - Raz, Dan J.

AU - Segal, Eran

AU - Wargo, Jennifer A.

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AU - Shental, Noam

AU - Straussman, Ravid

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The human tumor microbiome is composed of tumor type-specific intracellular bacteria

Resumen

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ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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