The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer’s Disease

Manuela Pietzuch; Anna E. King; David D. Ward; James C. Vickers

doi:10.3389/fnagi.2019.00030

The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer’s Disease

Manuela Pietzuch, Anna E. King, David D. Ward, James C. Vickers

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

34 Citas (Scopus)

Resumen

Magnetic resonance imaging (MRI) offers significant insight into the complex organization of neural networks within the human brain. Using resting-state functional MRI data, topological maps can be created to visualize changes in brain activity, as well as to represent and assess the structural and functional connections between different brain regions. Crucially, Alzheimer’s disease (AD) is associated with progressive loss in this connectivity, which is particularly evident within the default mode network. In this paper, we review the recent literature on how factors that are associated with risk of dementia may influence the organization of the brain network structures. In particular, we focus on cognitive reserve and the common genetic polymorphisms of APOE and BDNF Val66Met.

Idioma original	English
Número de artículo	30
Publicación	Frontiers in Aging Neuroscience
Volumen	11
DOI	https://doi.org/10.3389/fnagi.2019.00030
Estado	Published - mar. 6 2019
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
The authors wish to acknowledge and thank Mr. Graeme McCormack, Aidan Bindoff, and Prof. Robert Glew for assistance and contribution toward this project. Funding. Funding for the Wicking Centre was provided by the JO and JR Wicking Trust (Equity Trustees).

Publisher Copyright:
© Copyright © 2019 Pietzuch, King, Ward and Vickers.

ASJC Scopus Subject Areas

Ageing
Cognitive Neuroscience

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Journal Article
Review

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The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer’s Disease. / Pietzuch, Manuela; King, Anna E.; Ward, David D. et al.
En: Frontiers in Aging Neuroscience, Vol. 11, 30, 06.03.2019.

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

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The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer’s Disease

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODS de las Naciones Unidas

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