The network map of Elabela signaling pathway in physiological and pathological conditions

Shobha Dagamajalu; D. A.B. Rex; G. P. Suchitha; Akhila B. Rai; Jan K. Rainey; T. S.Keshava Prasad

doi:10.1007/s12079-021-00640-4

The network map of Elabela signaling pathway in physiological and pathological conditions

Shobha Dagamajalu, D. A.B. Rex, G. P. Suchitha, Akhila B. Rai, Jan K. Rainey, T. S.Keshava Prasad

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

9 Citas (Scopus)

Resumen

Elabela (ELA; also called Apela and Toddler) is one of the recently discovered ligand among the two endogenous peptide ligands (Apelin and Elabela) of the apelin receptor (APLNR, also known as APJ). Elabela-induced signaling plays a crucial role in diverse biological processes, including formation of the embryonic cardiovascular system and early placental development by reducing the chances of occurrence of preeclampsia during pregnancy. It also plays the major role in the renoprotection by reducing kidney injury and the inflammatory response and regulation of gene expression associated with heart failure and fibrosis. Elabela may be processed into different active peptides, each of which binds to APLNR and predominantly activates the signals through PI3K/AKT pathway. Owing to its biomedical importance, we developed a consolidated signaling map of Elabela, in accordance with the NetPath criteria. The presented Elabela signaling map comprises 12 activation/inhibition events, 15 catalysis events, 1 molecular association, 34 gene regulation events and 32 protein expression events. The Elabela signaling pathway map is freely made available through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway:WP5100).

Idioma original	English
Páginas (desde-hasta)	145-154
Número de páginas	10
Publicación	Journal of Cell Communication and Signaling
Volumen	16
N.º	1
DOI	https://doi.org/10.1007/s12079-021-00640-4
Estado	Published - mar. 2022

Nota bibliográfica

Funding Information:
We thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka, for the support to Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme in Multiomics Technology (BiSEP GO ITD 02 MDA 2017). RDAB is a recipient of the Senior Research Fellowship from the Indian Council of Medical Research (ICMR), Government of India. JKR is grateful for funding from the Canadian Institutes of Health Research (Operating Grant MOP-111138) and Research Nova Scotia (Development and Innovative Grant #MEDI-2019-2022).

Funding Information:
We thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka, for the support to Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme in Multiomics Technology (BiSEP GO ITD 02 MDA 2017). RDAB is a recipient of the Senior Research Fellowship from the Indian Council of Medical Research (ICMR), Government of India. JKR is grateful for funding from the Canadian Institutes of Health Research (Operating Grant MOP-111138) and Research Nova Scotia (Development and Innovative Grant #MEDI-2019-2022).

Publisher Copyright:
© 2021, The International CCN Society.

ASJC Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

PubMed: MeSH publication types

Journal Article

Acceder al documento

10.1007/s12079-021-00640-4

Otros archivos y enlaces

Citar esto

@article{256d81ac36c34dd4a624a329dded958c,

title = "The network map of Elabela signaling pathway in physiological and pathological conditions",

abstract = "Elabela (ELA; also called Apela and Toddler) is one of the recently discovered ligand among the two endogenous peptide ligands (Apelin and Elabela) of the apelin receptor (APLNR, also known as APJ). Elabela-induced signaling plays a crucial role in diverse biological processes, including formation of the embryonic cardiovascular system and early placental development by reducing the chances of occurrence of preeclampsia during pregnancy. It also plays the major role in the renoprotection by reducing kidney injury and the inflammatory response and regulation of gene expression associated with heart failure and fibrosis. Elabela may be processed into different active peptides, each of which binds to APLNR and predominantly activates the signals through PI3K/AKT pathway. Owing to its biomedical importance, we developed a consolidated signaling map of Elabela, in accordance with the NetPath criteria. The presented Elabela signaling map comprises 12 activation/inhibition events, 15 catalysis events, 1 molecular association, 34 gene regulation events and 32 protein expression events. The Elabela signaling pathway map is freely made available through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway:WP5100).",

author = "Shobha Dagamajalu and Rex, {D. A.B.} and Suchitha, {G. P.} and Rai, {Akhila B.} and Rainey, {Jan K.} and Prasad, {T. S.Keshava}",

note = "Funding Information: We thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka, for the support to Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme in Multiomics Technology (BiSEP GO ITD 02 MDA 2017). RDAB is a recipient of the Senior Research Fellowship from the Indian Council of Medical Research (ICMR), Government of India. JKR is grateful for funding from the Canadian Institutes of Health Research (Operating Grant MOP-111138) and Research Nova Scotia (Development and Innovative Grant #MEDI-2019-2022). Funding Information: We thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka, for the support to Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme in Multiomics Technology (BiSEP GO ITD 02 MDA 2017). RDAB is a recipient of the Senior Research Fellowship from the Indian Council of Medical Research (ICMR), Government of India. JKR is grateful for funding from the Canadian Institutes of Health Research (Operating Grant MOP-111138) and Research Nova Scotia (Development and Innovative Grant #MEDI-2019-2022). Publisher Copyright: {\textcopyright} 2021, The International CCN Society.",

year = "2022",

month = mar,

doi = "10.1007/s12079-021-00640-4",

language = "English",

volume = "16",

pages = "145--154",

journal = "Journal of Cell Communication and Signaling",

issn = "1873-9601",

publisher = "Springer Netherlands",

number = "1",

}

TY - JOUR

T1 - The network map of Elabela signaling pathway in physiological and pathological conditions

AU - Dagamajalu, Shobha

AU - Rex, D. A.B.

AU - Suchitha, G. P.

AU - Rai, Akhila B.

AU - Rainey, Jan K.

AU - Prasad, T. S.Keshava

N1 - Funding Information: We thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka, for the support to Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme in Multiomics Technology (BiSEP GO ITD 02 MDA 2017). RDAB is a recipient of the Senior Research Fellowship from the Indian Council of Medical Research (ICMR), Government of India. JKR is grateful for funding from the Canadian Institutes of Health Research (Operating Grant MOP-111138) and Research Nova Scotia (Development and Innovative Grant #MEDI-2019-2022). Funding Information: We thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka, for the support to Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme in Multiomics Technology (BiSEP GO ITD 02 MDA 2017). RDAB is a recipient of the Senior Research Fellowship from the Indian Council of Medical Research (ICMR), Government of India. JKR is grateful for funding from the Canadian Institutes of Health Research (Operating Grant MOP-111138) and Research Nova Scotia (Development and Innovative Grant #MEDI-2019-2022). Publisher Copyright: © 2021, The International CCN Society.

PY - 2022/3

Y1 - 2022/3

N2 - Elabela (ELA; also called Apela and Toddler) is one of the recently discovered ligand among the two endogenous peptide ligands (Apelin and Elabela) of the apelin receptor (APLNR, also known as APJ). Elabela-induced signaling plays a crucial role in diverse biological processes, including formation of the embryonic cardiovascular system and early placental development by reducing the chances of occurrence of preeclampsia during pregnancy. It also plays the major role in the renoprotection by reducing kidney injury and the inflammatory response and regulation of gene expression associated with heart failure and fibrosis. Elabela may be processed into different active peptides, each of which binds to APLNR and predominantly activates the signals through PI3K/AKT pathway. Owing to its biomedical importance, we developed a consolidated signaling map of Elabela, in accordance with the NetPath criteria. The presented Elabela signaling map comprises 12 activation/inhibition events, 15 catalysis events, 1 molecular association, 34 gene regulation events and 32 protein expression events. The Elabela signaling pathway map is freely made available through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway:WP5100).

AB - Elabela (ELA; also called Apela and Toddler) is one of the recently discovered ligand among the two endogenous peptide ligands (Apelin and Elabela) of the apelin receptor (APLNR, also known as APJ). Elabela-induced signaling plays a crucial role in diverse biological processes, including formation of the embryonic cardiovascular system and early placental development by reducing the chances of occurrence of preeclampsia during pregnancy. It also plays the major role in the renoprotection by reducing kidney injury and the inflammatory response and regulation of gene expression associated with heart failure and fibrosis. Elabela may be processed into different active peptides, each of which binds to APLNR and predominantly activates the signals through PI3K/AKT pathway. Owing to its biomedical importance, we developed a consolidated signaling map of Elabela, in accordance with the NetPath criteria. The presented Elabela signaling map comprises 12 activation/inhibition events, 15 catalysis events, 1 molecular association, 34 gene regulation events and 32 protein expression events. The Elabela signaling pathway map is freely made available through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway:WP5100).

UR - http://www.scopus.com/inward/record.url?scp=85111647497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85111647497&partnerID=8YFLogxK

U2 - 10.1007/s12079-021-00640-4

DO - 10.1007/s12079-021-00640-4

M3 - Article

C2 - 34339006

AN - SCOPUS:85111647497

SN - 1873-9601

VL - 16

SP - 145

EP - 154

JO - Journal of Cell Communication and Signaling

JF - Journal of Cell Communication and Signaling

IS - 1

ER -

The network map of Elabela signaling pathway in physiological and pathological conditions

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto