TY - JOUR
T1 - The ocular pathology in Leber's congenital amaurosis
AU - Sullivan, T. J.
AU - Heathcote, J. G.
AU - Brazel, S. M.
AU - Musarella, M. A.
PY - 1994
Y1 - 1994
N2 - Purpose: To present the ocular pathology of a three-year-old child with Leber's congenital amaurosis (LCA) who died from an unrelated episode of presumed viral meningitis. Methods: Autopsy was performed, and in addition the globes were harvested for pathological examination. Before the child's death, known systemic disorders with infantile retinal dystrophy were excluded. Results: The outer nuclear layer and photoreceptor layers are the primary site of retinal pathology in LCA. Conclusion: This report of the pathological findings in LCA, early in the natural history of the disease, indicates that process appears to be a degeneration rather than an agenesis.
AB - Purpose: To present the ocular pathology of a three-year-old child with Leber's congenital amaurosis (LCA) who died from an unrelated episode of presumed viral meningitis. Methods: Autopsy was performed, and in addition the globes were harvested for pathological examination. Before the child's death, known systemic disorders with infantile retinal dystrophy were excluded. Results: The outer nuclear layer and photoreceptor layers are the primary site of retinal pathology in LCA. Conclusion: This report of the pathological findings in LCA, early in the natural history of the disease, indicates that process appears to be a degeneration rather than an agenesis.
UR - http://www.scopus.com/inward/record.url?scp=0028354726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028354726&partnerID=8YFLogxK
U2 - 10.1111/j.1442-9071.1994.tb01691.x
DO - 10.1111/j.1442-9071.1994.tb01691.x
M3 - Article
C2 - 8037910
AN - SCOPUS:0028354726
SN - 0814-9763
VL - 22
SP - 25
EP - 31
JO - Australian and New Zealand Journal of Ophthalmology
JF - Australian and New Zealand Journal of Ophthalmology
IS - 1
ER -