The role of chemokines and chemokine receptors in alloantigen-independent and alloantigen-dependent transplantation injury

Mark E. DeVries, Karoline A. Hosiawa, Cheryl M. Cameron, Steven E. Bosinger, Desmond Persad, Alyson A. Kelvin, Jeff C. Coombs, Hao Wang, Robert Zhong, Mark J. Cameron, David J. Kelvin

Producción científica: Contribución a una revistaEncuesta cortarevisión exhaustiva

41 Citas (Scopus)

Resumen

Transplantation injury and rejection involves the interplay of innate and acquired immune responses. Immune-related injury manifests itself in three temporal phases: early innate immune driven alloantigen-independent injury, acquired immune driven alloantigen-dependent injury, and chronic injury. Sequential waves of chemokine expression play a central role in regulating graft injury through the recruitment of phagocytes shortly after transplantation and activated lymphocytes and phagocytes in the weeks and years following transplantation. This review focuses on recent studies demonstrating the role of chemokines in transplantation.

Idioma originalEnglish
Páginas (desde-hasta)33-48
Número de páginas16
PublicaciónSeminars in Immunology
Volumen15
N.º1
DOI
EstadoPublished - feb. 2003
Publicado de forma externa

Nota bibliográfica

Funding Information:
This work was supported by grants from the Heart and Stroke Foundation of Canada, the Canadian Institute of Health Research, and Genome Canada.

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

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