The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals

Maria Pannese; Giuseppe Lupo; Boris Kablar; Edoardo Boncinelli; Giuseppina Barsacchi; Robert Vignali

doi:10.1016/S0925-4773(98)00034-3

The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals

Maria Pannese, Giuseppe Lupo, Boris Kablar, Edoardo Boncinelli, Giuseppina Barsacchi, Robert Vignali

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

62 Citas (Scopus)

Resumen

We have isolated and studied the expression pattern of Xemx1 and Xerox2 genes in Xenopus laevis. Xemx genes are the homologues of mouse Emx genes, related to Drosophila empty spiracles. They are expressed in selected regions of the developing brain, particularly in the telencephalon, and, outside the brain, in the otic vesicles, olfactory placodes, visceral arches and the developing excretory system. We also report on experiments concerning the tissue and molecular signals responsible for their activation in competent ectoderm. Xerox genes are activated in ectoderm conjugated with head organizer tissue, but not with tail organizer tissue. Furthermore, they are not activated in animal caps either by noggin or by Xnr3, thus suggesting that a different inducer or the integration of several signals may be responsible for their activation.

Idioma original	English
Páginas (desde-hasta)	73-83
Número de páginas	11
Publicación	Mechanisms of Development
Volumen	73
N.º	1
DOI	https://doi.org/10.1016/S0925-4773(98)00034-3
Estado	Published - abr. 1998
Publicado de forma externa	Sí

Nota bibliográfica

Funding Information:
We wish to thank Richard Harland, Paul Krieg, Nancy Papalopulu for the generous gift of constructs and Igor Dawid for the cDNA library. Special thanks to Scott Stachel and Richard Harland for allowing us to use Xotx - b as a marker prior to publication. We thank Bill Smith for advice on Xnr3 mRNA microinjections. We also thank Donatella De Matienzo and Marzia Fabbri for essential technical assistance. This work was supported by grants from MURST and from Progetto Finalizzato CNR `Ingegneria Genetica'. G.L. is a recipient of a PhD fellowship from the Italian Government.

ASJC Scopus Subject Areas

Embryology
Developmental Biology

Acceder al documento

10.1016/S0925-4773(98)00034-3

Otros archivos y enlaces

Citar esto

@article{1eac1d4bde4346e99c117201b97d97a0,

title = "The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals",

abstract = "We have isolated and studied the expression pattern of Xemx1 and Xerox2 genes in Xenopus laevis. Xemx genes are the homologues of mouse Emx genes, related to Drosophila empty spiracles. They are expressed in selected regions of the developing brain, particularly in the telencephalon, and, outside the brain, in the otic vesicles, olfactory placodes, visceral arches and the developing excretory system. We also report on experiments concerning the tissue and molecular signals responsible for their activation in competent ectoderm. Xerox genes are activated in ectoderm conjugated with head organizer tissue, but not with tail organizer tissue. Furthermore, they are not activated in animal caps either by noggin or by Xnr3, thus suggesting that a different inducer or the integration of several signals may be responsible for their activation.",

author = "Maria Pannese and Giuseppe Lupo and Boris Kablar and Edoardo Boncinelli and Giuseppina Barsacchi and Robert Vignali",

note = "Funding Information: We wish to thank Richard Harland, Paul Krieg, Nancy Papalopulu for the generous gift of constructs and Igor Dawid for the cDNA library. Special thanks to Scott Stachel and Richard Harland for allowing us to use Xotx - b as a marker prior to publication. We thank Bill Smith for advice on Xnr3 mRNA microinjections. We also thank Donatella De Matienzo and Marzia Fabbri for essential technical assistance. This work was supported by grants from MURST and from Progetto Finalizzato CNR `Ingegneria Genetica'. G.L. is a recipient of a PhD fellowship from the Italian Government. ",

year = "1998",

month = apr,

doi = "10.1016/S0925-4773(98)00034-3",

language = "English",

volume = "73",

pages = "73--83",

journal = "Mechanisms of Development",

issn = "0925-4773",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals

AU - Pannese, Maria

AU - Lupo, Giuseppe

AU - Kablar, Boris

AU - Boncinelli, Edoardo

AU - Barsacchi, Giuseppina

AU - Vignali, Robert

N1 - Funding Information: We wish to thank Richard Harland, Paul Krieg, Nancy Papalopulu for the generous gift of constructs and Igor Dawid for the cDNA library. Special thanks to Scott Stachel and Richard Harland for allowing us to use Xotx - b as a marker prior to publication. We thank Bill Smith for advice on Xnr3 mRNA microinjections. We also thank Donatella De Matienzo and Marzia Fabbri for essential technical assistance. This work was supported by grants from MURST and from Progetto Finalizzato CNR `Ingegneria Genetica'. G.L. is a recipient of a PhD fellowship from the Italian Government.

PY - 1998/4

Y1 - 1998/4

N2 - We have isolated and studied the expression pattern of Xemx1 and Xerox2 genes in Xenopus laevis. Xemx genes are the homologues of mouse Emx genes, related to Drosophila empty spiracles. They are expressed in selected regions of the developing brain, particularly in the telencephalon, and, outside the brain, in the otic vesicles, olfactory placodes, visceral arches and the developing excretory system. We also report on experiments concerning the tissue and molecular signals responsible for their activation in competent ectoderm. Xerox genes are activated in ectoderm conjugated with head organizer tissue, but not with tail organizer tissue. Furthermore, they are not activated in animal caps either by noggin or by Xnr3, thus suggesting that a different inducer or the integration of several signals may be responsible for their activation.

AB - We have isolated and studied the expression pattern of Xemx1 and Xerox2 genes in Xenopus laevis. Xemx genes are the homologues of mouse Emx genes, related to Drosophila empty spiracles. They are expressed in selected regions of the developing brain, particularly in the telencephalon, and, outside the brain, in the otic vesicles, olfactory placodes, visceral arches and the developing excretory system. We also report on experiments concerning the tissue and molecular signals responsible for their activation in competent ectoderm. Xerox genes are activated in ectoderm conjugated with head organizer tissue, but not with tail organizer tissue. Furthermore, they are not activated in animal caps either by noggin or by Xnr3, thus suggesting that a different inducer or the integration of several signals may be responsible for their activation.

UR - http://www.scopus.com/inward/record.url?scp=0031970788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031970788&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(98)00034-3

DO - 10.1016/S0925-4773(98)00034-3

M3 - Article

C2 - 9545539

AN - SCOPUS:0031970788

SN - 0925-4773

VL - 73

SP - 73

EP - 83

JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1

ER -

The Xenopus Emx genes identify presumptive dorsal telencephalon and are induced by head organizer signals

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto