Tissue distribution of ethosuximide and clobazam in a seizure related fatality

A. D. Fraser; A. F. Isner; S. A. Heifetz

doi:10.1520/jfs12532j

Tissue distribution of ethosuximide and clobazam in a seizure related fatality

A. D. Fraser, A. F. Isner, S. A. Heifetz

Medicine

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3 Citas (Scopus)

Resumen

The case of a six-year-old male who died in a hospital receiving several anti-convulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.

Idioma original	English
Páginas (desde-hasta)	1058-1063
Número de páginas	6
Publicación	Journal of Forensic Sciences
Volumen	33
N.º	4
DOI	https://doi.org/10.1520/jfs12532j
Estado	Published - 1988

ASJC Scopus Subject Areas

Pathology and Forensic Medicine
Genetics

PubMed: MeSH publication types

Case Reports
Journal Article

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abstract = "The case of a six-year-old male who died in a hospital receiving several anti-convulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.",

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AU - Isner, A. F.

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N2 - The case of a six-year-old male who died in a hospital receiving several anti-convulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.

AB - The case of a six-year-old male who died in a hospital receiving several anti-convulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.

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Tissue distribution of ethosuximide and clobazam in a seizure related fatality

Resumen

ASJC Scopus Subject Areas

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