TY - JOUR
T1 - Vasculitis as an adverse event following immunization – Systematic literature review
AU - Bonetto, Caterina
AU - Trotta, Francesco
AU - Felicetti, Patrizia
AU - Alarcón, Graciela S.
AU - Santuccio, Carmela
AU - Bachtiar, Novilia Sjafri
AU - Brauchli Pernus, Yolanda
AU - Chandler, Rebecca
AU - Girolomoni, Giampiero
AU - Hadden, Robert D.M.
AU - Kucuku, Merita
AU - Ozen, Seza
AU - Pahud, Barbara
AU - Top, Karina
AU - Varricchio, Frederick
AU - Wise, Robert P.
AU - Zanoni, Giovanna
AU - Živković, Saša
AU - Bonhoeffer, Jan
N1 - Publisher Copyright:
© 2015
PY - 2016/12/12
Y1 - 2016/12/12
N2 - Background Several types of vasculitis have been observed and reported in temporal association with the administration of various vaccines. A systematic review of current evidence is lacking. Objective This systematic literature review aimed to assess available evidence and current reporting practice of vasculitides as adverse events following immunization (AEFI). Methods We reviewed the literature from 1st January 1994 to 30th June 2014. This review comprises randomized controlled trials, observational studies, case series, case reports, reviews and comments regardless of vaccine and target population. Results The initial search resulted in the identification of 6656 articles. Of these, 157 articles were assessed for eligibility and 75 studies were considered for analysis, including 6 retrospective/observational studies, 2 randomized controlled trials, 7 reviews, 11 case series, 46 case reports and 3 comments. Most of the larger, higher quality studies found no causal association between vaccination and subsequent development of vasculitis, including several studies on Kawasaki disease and Henoch-Schönlein purpura (IgA vasculitis). Smaller case series reported a few cases of vasculitis following BCG and vaccines against influenza and hepatitis. Only 24% of the articles reported using a case definition of vasculitis. Conclusions Existing literature does not allow establishing a causative link between vaccination and vasculitides. Further investigations were strengthened by the use of standardized case definitions and methods for data collection, analysis and presentation to improve data comparability and interpretation of vasculitis cases following immunization.
AB - Background Several types of vasculitis have been observed and reported in temporal association with the administration of various vaccines. A systematic review of current evidence is lacking. Objective This systematic literature review aimed to assess available evidence and current reporting practice of vasculitides as adverse events following immunization (AEFI). Methods We reviewed the literature from 1st January 1994 to 30th June 2014. This review comprises randomized controlled trials, observational studies, case series, case reports, reviews and comments regardless of vaccine and target population. Results The initial search resulted in the identification of 6656 articles. Of these, 157 articles were assessed for eligibility and 75 studies were considered for analysis, including 6 retrospective/observational studies, 2 randomized controlled trials, 7 reviews, 11 case series, 46 case reports and 3 comments. Most of the larger, higher quality studies found no causal association between vaccination and subsequent development of vasculitis, including several studies on Kawasaki disease and Henoch-Schönlein purpura (IgA vasculitis). Smaller case series reported a few cases of vasculitis following BCG and vaccines against influenza and hepatitis. Only 24% of the articles reported using a case definition of vasculitis. Conclusions Existing literature does not allow establishing a causative link between vaccination and vasculitides. Further investigations were strengthened by the use of standardized case definitions and methods for data collection, analysis and presentation to improve data comparability and interpretation of vasculitis cases following immunization.
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U2 - 10.1016/j.vaccine.2015.09.026
DO - 10.1016/j.vaccine.2015.09.026
M3 - Review article
C2 - 26398442
AN - SCOPUS:84948845957
SN - 0264-410X
VL - 34
SP - 6641
EP - 6651
JO - Vaccine
JF - Vaccine
IS - 51
ER -