TY - JOUR
T1 - Viruses and Mammalian Chromosomes VII. The Persistence of a Chromosomal Instability in Regenerating, Transplanted, and Cultured Neoplasms Induced by Human Adenovirus Type 12 in Syrian Hamsters
AU - Stoltz, D. B.
AU - Stich, H. F.
AU - Yohn, D. S.
PY - 1967/3
Y1 - 1967/3
N2 - The incidence of cells with karyotypic abnormalities, such as pseudodiploidy and aneuploidy, and of cells with chromosome aberrations, including breaks, fragmentations, and coiling anomalies, was estimated in regenerating, transplanted, and cultured neoplasms induced in Syrian hamsters by human Adenovirus type 12. The various neoplasms studied consisted of karyotypically heterogeneous cell populations. Numerous clones with particular chromosome complements were present, but stemlines were not a dominant feature of the neoplastic cell populations examined. A relatively high incidence of chromosome aberration persisted in all neoplasms. A possible relationship between retention of the viral genome or part of it in the neoplastic cells and the persistence of a chromosome instability and the significance of chromosome aberration in Adenovirus-12-induced oncogenesis are discussed.
AB - The incidence of cells with karyotypic abnormalities, such as pseudodiploidy and aneuploidy, and of cells with chromosome aberrations, including breaks, fragmentations, and coiling anomalies, was estimated in regenerating, transplanted, and cultured neoplasms induced in Syrian hamsters by human Adenovirus type 12. The various neoplasms studied consisted of karyotypically heterogeneous cell populations. Numerous clones with particular chromosome complements were present, but stemlines were not a dominant feature of the neoplastic cell populations examined. A relatively high incidence of chromosome aberration persisted in all neoplasms. A possible relationship between retention of the viral genome or part of it in the neoplastic cells and the persistence of a chromosome instability and the significance of chromosome aberration in Adenovirus-12-induced oncogenesis are discussed.
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M3 - Article
C2 - 6021516
AN - SCOPUS:0014059956
SN - 0008-5472
VL - 27
SP - 587
EP - 598
JO - Cancer Research
JF - Cancer Research
IS - 3
ER -