Viruses and Mammalian Chromosomes VII. The Persistence of a Chromosomal Instability in Regenerating, Transplanted, and Cultured Neoplasms Induced by Human Adenovirus Type 12 in Syrian Hamsters

D. B. Stoltz, H. F. Stich, D. S. Yohn

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

9 Citas (Scopus)

Resumen

The incidence of cells with karyotypic abnormalities, such as pseudodiploidy and aneuploidy, and of cells with chromosome aberrations, including breaks, fragmentations, and coiling anomalies, was estimated in regenerating, transplanted, and cultured neoplasms induced in Syrian hamsters by human Adenovirus type 12. The various neoplasms studied consisted of karyotypically heterogeneous cell populations. Numerous clones with particular chromosome complements were present, but stemlines were not a dominant feature of the neoplastic cell populations examined. A relatively high incidence of chromosome aberration persisted in all neoplasms. A possible relationship between retention of the viral genome or part of it in the neoplastic cells and the persistence of a chromosome instability and the significance of chromosome aberration in Adenovirus-12-induced oncogenesis are discussed.

Idioma originalEnglish
Páginas (desde-hasta)587-598
Número de páginas12
PublicaciónCancer Research
Volumen27
N.º3
EstadoPublished - mar. 1967
Publicado de forma externa

ASJC Scopus Subject Areas

  • Oncology
  • Cancer Research

Huella

Profundice en los temas de investigación de 'Viruses and Mammalian Chromosomes VII. The Persistence of a Chromosomal Instability in Regenerating, Transplanted, and Cultured Neoplasms Induced by Human Adenovirus Type 12 in Syrian Hamsters'. En conjunto forman una huella única.

Citar esto