Visual memory and psychotic symptoms in youth

Emily Howes Vallis; Lynn E. MacKenzie; Alyson Zwicker; Vladislav Drobinin; Sheri Rempel; Sabina Abidi; David Lovas; Alexa Bagnell; Lukas Propper; Antonina Omisade; Helen L. Fisher; Barbara Pavlova; Rudolf Uher

doi:10.1080/13546805.2020.1741342

Visual memory and psychotic symptoms in youth

Emily Howes Vallis, Lynn E. MacKenzie, Alyson Zwicker, Vladislav Drobinin, Sheri Rempel, Sabina Abidi, David Lovas, Alexa Bagnell, Lukas Propper, Antonina Omisade, Helen L. Fisher, Barbara Pavlova, Rudolf Uher

Medicine

Medicine

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2 Citas (Scopus)

Resumen

Background: Psychotic symptoms are common during childhood and adolescence and may indicate transdiagnostic risk of future psychiatric disorders. Lower visual memory ability has been suggested as a potential indicator of future risk of mental illness. The relationship between visual memory and clinician-confirmed definite psychotic symptoms in youth has not yet been explored. Methods: We examined visual memory and psychotic symptoms among 205 participants aged 7–27 years in a cohort enriched for parental mood and psychotic disorders. We assessed visual memory using the Rey Complex Figure Test (RCFT) and psychotic symptoms using validated semi-structured interview measures. We tested the relationship between visual memory and psychotic symptoms using mixed-effects logistic regression. Results: After accounting for age, sex, and family clustering, we found that psychotic symptoms were significantly associated with lower visual memory (OR = 1.80, 95% CI 1.06–3.06, p = 0.030). This result was unchanged after accounting for general cognitive ability. Conclusion: Lower visual memory performance is associated with psychotic symptoms among youth, regardless of general cognitive ability. This finding may inform future targeted early interventions.

Idioma original	English
Páginas (desde-hasta)	231-241
Número de páginas	11
Publicación	Cognitive Neuropsychiatry
Volumen	25
N.º	3
DOI	https://doi.org/10.1080/13546805.2020.1741342
Estado	Published - may. 3 2020

Nota bibliográfica

Funding Information:
The work has been generously supported by funding from the Canada Research Chairs Programme (Award Number 231397), the Canadian Institutes of Health Research (Grant reference numbers 124976, 142738 and 148394), the Brain & Behaviour Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (Grants 275319, 1716 and 353892), the Dalhousie Medical Research Foundation, and the Sutton Family. Dr. Helen L. Fisher is supported by a British Academy Mid-Career Fellowship (MD\170005). Ms. Howes Vallis and Dr. Zwicker have been supported by the Lindsay Family Graduate Studentships. Mr. Drobinin was supported by the CIHR Doctoral Award (157975).

Funding Information:
This work was supported by Brain and Behavior Research Foundation: [Grant Number 24684]; British Academy: [Grant Number 170005]; Canada Research Chairs: [Grant Number 231397]; Canadian Institutes of Health Research: [Grant Number 124976,142738,148394,157975]; Dalhousie Medical Research Foundation: [Grant Number Lindsay Family Graduate Studentships]; Nova Scotia Health Research Foundation: [Grant Number 1716,275319,353892]. The work has been generously supported by funding from the Canada Research Chairs Programme (Award Number 231397), the Canadian Institutes of Health Research (Grant reference numbers 124976, 142738 and 148394), the Brain & Behaviour Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (Grants 275319, 1716 and 353892), the Dalhousie Medical Research Foundation, and the Sutton Family. Dr. Helen L. Fisher is supported by a British Academy Mid-Career Fellowship (MD\170005). Ms. Howes Vallis and Dr. Zwicker have been supported by the Lindsay Family Graduate Studentships. Mr. Drobinin was supported by the CIHR Doctoral Award (157975).

Publisher Copyright:
© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

ASJC Scopus Subject Areas

Cognitive Neuroscience
Psychiatry and Mental health

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@article{1e965bb3edb544dbacb718ee430a4472,

title = "Visual memory and psychotic symptoms in youth",

abstract = "Background: Psychotic symptoms are common during childhood and adolescence and may indicate transdiagnostic risk of future psychiatric disorders. Lower visual memory ability has been suggested as a potential indicator of future risk of mental illness. The relationship between visual memory and clinician-confirmed definite psychotic symptoms in youth has not yet been explored. Methods: We examined visual memory and psychotic symptoms among 205 participants aged 7–27 years in a cohort enriched for parental mood and psychotic disorders. We assessed visual memory using the Rey Complex Figure Test (RCFT) and psychotic symptoms using validated semi-structured interview measures. We tested the relationship between visual memory and psychotic symptoms using mixed-effects logistic regression. Results: After accounting for age, sex, and family clustering, we found that psychotic symptoms were significantly associated with lower visual memory (OR = 1.80, 95% CI 1.06–3.06, p = 0.030). This result was unchanged after accounting for general cognitive ability. Conclusion: Lower visual memory performance is associated with psychotic symptoms among youth, regardless of general cognitive ability. This finding may inform future targeted early interventions.",

author = "{Howes Vallis}, Emily and MacKenzie, {Lynn E.} and Alyson Zwicker and Vladislav Drobinin and Sheri Rempel and Sabina Abidi and David Lovas and Alexa Bagnell and Lukas Propper and Antonina Omisade and Fisher, {Helen L.} and Barbara Pavlova and Rudolf Uher",

note = "Funding Information: The work has been generously supported by funding from the Canada Research Chairs Programme (Award Number 231397), the Canadian Institutes of Health Research (Grant reference numbers 124976, 142738 and 148394), the Brain & Behaviour Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (Grants 275319, 1716 and 353892), the Dalhousie Medical Research Foundation, and the Sutton Family. Dr. Helen L. Fisher is supported by a British Academy Mid-Career Fellowship (MD\170005). Ms. Howes Vallis and Dr. Zwicker have been supported by the Lindsay Family Graduate Studentships. Mr. Drobinin was supported by the CIHR Doctoral Award (157975). Funding Information: This work was supported by Brain and Behavior Research Foundation: [Grant Number 24684]; British Academy: [Grant Number 170005]; Canada Research Chairs: [Grant Number 231397]; Canadian Institutes of Health Research: [Grant Number 124976,142738,148394,157975]; Dalhousie Medical Research Foundation: [Grant Number Lindsay Family Graduate Studentships]; Nova Scotia Health Research Foundation: [Grant Number 1716,275319,353892]. The work has been generously supported by funding from the Canada Research Chairs Programme (Award Number 231397), the Canadian Institutes of Health Research (Grant reference numbers 124976, 142738 and 148394), the Brain & Behaviour Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (Grants 275319, 1716 and 353892), the Dalhousie Medical Research Foundation, and the Sutton Family. Dr. Helen L. Fisher is supported by a British Academy Mid-Career Fellowship (MD\170005). Ms. Howes Vallis and Dr. Zwicker have been supported by the Lindsay Family Graduate Studentships. Mr. Drobinin was supported by the CIHR Doctoral Award (157975). Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2020",

month = may,

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doi = "10.1080/13546805.2020.1741342",

language = "English",

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T1 - Visual memory and psychotic symptoms in youth

AU - Howes Vallis, Emily

AU - MacKenzie, Lynn E.

AU - Zwicker, Alyson

AU - Drobinin, Vladislav

AU - Rempel, Sheri

AU - Abidi, Sabina

AU - Lovas, David

AU - Bagnell, Alexa

AU - Propper, Lukas

AU - Omisade, Antonina

AU - Fisher, Helen L.

AU - Pavlova, Barbara

AU - Uher, Rudolf

N1 - Funding Information: The work has been generously supported by funding from the Canada Research Chairs Programme (Award Number 231397), the Canadian Institutes of Health Research (Grant reference numbers 124976, 142738 and 148394), the Brain & Behaviour Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (Grants 275319, 1716 and 353892), the Dalhousie Medical Research Foundation, and the Sutton Family. Dr. Helen L. Fisher is supported by a British Academy Mid-Career Fellowship (MD\170005). Ms. Howes Vallis and Dr. Zwicker have been supported by the Lindsay Family Graduate Studentships. Mr. Drobinin was supported by the CIHR Doctoral Award (157975). Funding Information: This work was supported by Brain and Behavior Research Foundation: [Grant Number 24684]; British Academy: [Grant Number 170005]; Canada Research Chairs: [Grant Number 231397]; Canadian Institutes of Health Research: [Grant Number 124976,142738,148394,157975]; Dalhousie Medical Research Foundation: [Grant Number Lindsay Family Graduate Studentships]; Nova Scotia Health Research Foundation: [Grant Number 1716,275319,353892]. The work has been generously supported by funding from the Canada Research Chairs Programme (Award Number 231397), the Canadian Institutes of Health Research (Grant reference numbers 124976, 142738 and 148394), the Brain & Behaviour Research Foundation (NARSAD) Independent Investigator Grant 24684, Nova Scotia Health Research Foundation (Grants 275319, 1716 and 353892), the Dalhousie Medical Research Foundation, and the Sutton Family. Dr. Helen L. Fisher is supported by a British Academy Mid-Career Fellowship (MD\170005). Ms. Howes Vallis and Dr. Zwicker have been supported by the Lindsay Family Graduate Studentships. Mr. Drobinin was supported by the CIHR Doctoral Award (157975). Publisher Copyright: © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2020/5/3

Y1 - 2020/5/3

N2 - Background: Psychotic symptoms are common during childhood and adolescence and may indicate transdiagnostic risk of future psychiatric disorders. Lower visual memory ability has been suggested as a potential indicator of future risk of mental illness. The relationship between visual memory and clinician-confirmed definite psychotic symptoms in youth has not yet been explored. Methods: We examined visual memory and psychotic symptoms among 205 participants aged 7–27 years in a cohort enriched for parental mood and psychotic disorders. We assessed visual memory using the Rey Complex Figure Test (RCFT) and psychotic symptoms using validated semi-structured interview measures. We tested the relationship between visual memory and psychotic symptoms using mixed-effects logistic regression. Results: After accounting for age, sex, and family clustering, we found that psychotic symptoms were significantly associated with lower visual memory (OR = 1.80, 95% CI 1.06–3.06, p = 0.030). This result was unchanged after accounting for general cognitive ability. Conclusion: Lower visual memory performance is associated with psychotic symptoms among youth, regardless of general cognitive ability. This finding may inform future targeted early interventions.

AB - Background: Psychotic symptoms are common during childhood and adolescence and may indicate transdiagnostic risk of future psychiatric disorders. Lower visual memory ability has been suggested as a potential indicator of future risk of mental illness. The relationship between visual memory and clinician-confirmed definite psychotic symptoms in youth has not yet been explored. Methods: We examined visual memory and psychotic symptoms among 205 participants aged 7–27 years in a cohort enriched for parental mood and psychotic disorders. We assessed visual memory using the Rey Complex Figure Test (RCFT) and psychotic symptoms using validated semi-structured interview measures. We tested the relationship between visual memory and psychotic symptoms using mixed-effects logistic regression. Results: After accounting for age, sex, and family clustering, we found that psychotic symptoms were significantly associated with lower visual memory (OR = 1.80, 95% CI 1.06–3.06, p = 0.030). This result was unchanged after accounting for general cognitive ability. Conclusion: Lower visual memory performance is associated with psychotic symptoms among youth, regardless of general cognitive ability. This finding may inform future targeted early interventions.

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Visual memory and psychotic symptoms in youth

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