2-(Alkoxyaryl)-2-imidazoline Monoamine Oxidase Inhibitors with Antidepressant Activity

Morton Harfenist, Francis E. Soroko, Gerald M. McKenzie

Résultat de recherche: Articleexamen par les pairs

38 Citations (Scopus)

Résumé

Unlike the related noncyclic amidines which are broad-spectrum cestocides, a number of 2-imidazolines substituted in the 2 position by alkoxyaryl groups were not highly active in screening tests against the mouse tapeworms Hymenolepis nana and Oochoristica symmetrica. Certain of the 2-(4-alkoxynaphthyl)-2-imidazolines and 2-(6-alkoxy-2-naphthyl)-2-imidzolines, however, had activity interpreted as antidepressant in the mouse. This activity paralleled in vitro irreversible inhibitory activity against mouse brain MAO for those where no substitution is present on the imidazoline ring. This irreversibility probably has a different origin from that postulated to explain the irreversible MAO inhibition of proparglic, cyclopropyl, and other “chemically reactive” MAO inhibitors.

Langue d'origineEnglish
Pages (de-à)405-409
Nombre de pages5
JournalJournal of Medicinal Chemistry
Volume21
Numéro de publication4
DOI
Statut de publicationPublished - 1978
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Molecular Medicine
  • Drug Discovery

PubMed: MeSH publication types

  • Journal Article

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