A procedure for creating a frailty index based on deficit accumulation in aging mice

Randi J. Parks; Elias Fares; Jennifer K. MacDonald; Matthew C. Ernst; Christopher J. Sinal; Kenneth Rockwood; Susan E. Howlett

doi:10.1093/gerona/glr193

A procedure for creating a frailty index based on deficit accumulation in aging mice

Randi J. Parks, Elias Fares, Jennifer K. MacDonald, Matthew C. Ernst, Christopher J. Sinal, Kenneth Rockwood, Susan E. Howlett

Résultat de recherche: Article › examen par les pairs

166 Citations (Scopus)

Résumé

This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months) mice of both sexes. Aged animals had a higher FI than younger animals (FI = 0.43 ± 0.03 vs 0.08 ± 0.02, p <. 001, n = 12). Myocyte hypertrophy increased by 30%-50% as the FI increased in aged animals. Peak contractions decreased more than threefold from lowest to highest FI values in aged mice (p <.037), but calcium transients were unaffected. Similar results were seen with an FI based on eight noninvasive variables identified as underlying factors. These results show that an FI can be developed for murine models and suggest that age-associated changes in myocytes are more prominent in animals with a high FI.

Langue d'origine	English
Pages (de-à)	217-227
Nombre de pages	11
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	67 A
Numéro de publication	3
DOI	https://doi.org/10.1093/gerona/glr193
Statut de publication	Published - mars 2012

Note bibliographique

Funding Information:
This study was supported by grants from the Canadian Institutes for Health Research and the Heart and Stroke Foundations of New Brunswick and Nova Scotia. E.F. was supported by studentships from the Canadian Institutes for Health Research and the Nova Scotia Health Research Foundation. R.J.P was supported by a BrightRed graduate student research award from the Heart and Stroke Foundation of Nova Scotia. M.C.E was supported by a Nova Scotia Health Research Foundation studentship. K.R. receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research.

ASJC Scopus Subject Areas

Ageing
Geriatrics and Gerontology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

Accès au document

10.1093/gerona/glr193

Autres fichiers et liens

Citer

@article{d2b98c1d354846bb86056aea26a9fe98,

title = "A procedure for creating a frailty index based on deficit accumulation in aging mice",

abstract = "This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months) mice of both sexes. Aged animals had a higher FI than younger animals (FI = 0.43 ± 0.03 vs 0.08 ± 0.02, p <. 001, n = 12). Myocyte hypertrophy increased by 30%-50% as the FI increased in aged animals. Peak contractions decreased more than threefold from lowest to highest FI values in aged mice (p <.037), but calcium transients were unaffected. Similar results were seen with an FI based on eight noninvasive variables identified as underlying factors. These results show that an FI can be developed for murine models and suggest that age-associated changes in myocytes are more prominent in animals with a high FI.",

author = "Parks, {Randi J.} and Elias Fares and MacDonald, {Jennifer K.} and Ernst, {Matthew C.} and Sinal, {Christopher J.} and Kenneth Rockwood and Howlett, {Susan E.}",

note = "Funding Information: This study was supported by grants from the Canadian Institutes for Health Research and the Heart and Stroke Foundations of New Brunswick and Nova Scotia. E.F. was supported by studentships from the Canadian Institutes for Health Research and the Nova Scotia Health Research Foundation. R.J.P was supported by a BrightRed graduate student research award from the Heart and Stroke Foundation of Nova Scotia. M.C.E was supported by a Nova Scotia Health Research Foundation studentship. K.R. receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research.",

year = "2012",

month = mar,

doi = "10.1093/gerona/glr193",

language = "English",

volume = "67 A",

pages = "217--227",

journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - A procedure for creating a frailty index based on deficit accumulation in aging mice

AU - Parks, Randi J.

AU - Fares, Elias

AU - MacDonald, Jennifer K.

AU - Ernst, Matthew C.

AU - Sinal, Christopher J.

AU - Rockwood, Kenneth

AU - Howlett, Susan E.

N1 - Funding Information: This study was supported by grants from the Canadian Institutes for Health Research and the Heart and Stroke Foundations of New Brunswick and Nova Scotia. E.F. was supported by studentships from the Canadian Institutes for Health Research and the Nova Scotia Health Research Foundation. R.J.P was supported by a BrightRed graduate student research award from the Heart and Stroke Foundation of Nova Scotia. M.C.E was supported by a Nova Scotia Health Research Foundation studentship. K.R. receives career support from the Dalhousie Medical Research Foundation as the Kathryn Allen Weldon Professor of Alzheimer Research.

PY - 2012/3

Y1 - 2012/3

N2 - This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months) mice of both sexes. Aged animals had a higher FI than younger animals (FI = 0.43 ± 0.03 vs 0.08 ± 0.02, p <. 001, n = 12). Myocyte hypertrophy increased by 30%-50% as the FI increased in aged animals. Peak contractions decreased more than threefold from lowest to highest FI values in aged mice (p <.037), but calcium transients were unaffected. Similar results were seen with an FI based on eight noninvasive variables identified as underlying factors. These results show that an FI can be developed for murine models and suggest that age-associated changes in myocytes are more prominent in animals with a high FI.

AB - This study developed an approach to quantify frailty with a frailty index (FI) and investigated whether age-related changes in contractions, calcium transients, and ventricular myocyte length were more prominent in mice with a high FI. The FI combined 31 variables that reflect different aspects of health in middle-aged (∼12 months) and aged (∼30 months) mice of both sexes. Aged animals had a higher FI than younger animals (FI = 0.43 ± 0.03 vs 0.08 ± 0.02, p <. 001, n = 12). Myocyte hypertrophy increased by 30%-50% as the FI increased in aged animals. Peak contractions decreased more than threefold from lowest to highest FI values in aged mice (p <.037), but calcium transients were unaffected. Similar results were seen with an FI based on eight noninvasive variables identified as underlying factors. These results show that an FI can be developed for murine models and suggest that age-associated changes in myocytes are more prominent in animals with a high FI.

UR - http://www.scopus.com/inward/record.url?scp=84858038607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858038607&partnerID=8YFLogxK

U2 - 10.1093/gerona/glr193

DO - 10.1093/gerona/glr193

M3 - Article

C2 - 22021390

AN - SCOPUS:84858038607

SN - 1079-5006

VL - 67 A

SP - 217

EP - 227

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 3

ER -

A procedure for creating a frailty index based on deficit accumulation in aging mice

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer