A survey of factor prophylaxis in boys with haemophilia followed in North American haemophilia treatment centres

Victor S. Blanchette, M. McCready, C. Achonu, M. Abdolell, G. Rivard, M. Manco-Johnson

Résultat de recherche: Articleexamen par les pairs

60 Citations (Scopus)

Résumé

A survey was conducted in 2002 to determine the pattern of factor prophylaxis use in boys ≤18 years of age with haemophilia followed in North American treatment centres. Responses were obtained from 4553 cases (74% haemophilia A, 26% haemophilia B). The frequency of prophylaxis, defined as factor infusion greater than or equal to once per week for ≥45 weeks per year, was significantly higher for haemophilia A vs. haemophilia B cases (51% vs. 32%, P<0.0001), and for boys with severe haemophilia A living in Canada vs. the USA (77% vs. 47%, P<0.0001). Use of full-dose prophylaxis, defined as the infusion of 25-40 IU kg-1 of factor VIII on alternate days (minimum three times per week) or 25-40 IU kg-1 of factor IX twice weekly, was similar for boys ≤5 years of age in both Canada and the USA (30% and 33% haemophilia A and 35% and 13% haemophilia B). Reasons for initiating prophylaxis included a history of joint bleeding (88%) and age ≤2 years (23%). For prophylaxis triggered by joint bleeding, 38% of haemophilia treatment centres indicated that they would initiate prophylaxis after the first joint bleed and 66% after a history of target joint bleeding, defined most frequently as 2-4 bleeds over a 3-6 consecutive month period. A central venous line was used to ensure easy venous access for full-dose prophylaxis therapy in 80% of boys ≤5 years of age. These data offer a basis for projecting long-term factor concentrate needs for persons with haemophilia living in North America.

Langue d'origineEnglish
Pages (de-à)19-26
Nombre de pages8
JournalHaemophilia
Volume9
Numéro de publicationSUPPL. 1
DOI
Statut de publicationPublished - mai 2003
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Hematology
  • Genetics(clinical)

PubMed: MeSH publication types

  • Journal Article

Empreinte numérique

Plonger dans les sujets de recherche 'A survey of factor prophylaxis in boys with haemophilia followed in North American haemophilia treatment centres'. Ensemble, ils forment une empreinte numérique unique.

Citer