Accelerated elimination of N. brasiliensis from the small intestine after auto-anti-IgE induction

J. S. Marshall, P. D. Wells, E. B. Bell

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15 Citations (Scopus)

Résumé

Immunization of rats with a purified IgE myeloma (IR2) induced an auto-anti-IgE response. Such treatment inhibited total IgE levels in the serum of conventional IgE-producing rats (Marshall & Bell, 1985) and increased the number of mucosal mast cells (MMC) in the intestine. The present study has investigated the ability of auto-anti-IgE induction to influence the course of a Nippostrongylus brasiliensis infection, to modify IgE synthesis, or to affect the number of MMC in the intestine following infection. Auto-anti-IgE induction was found to have a surprising effect on worm elimination. IR2-immunized rats were able to rid themselves of this nematode with an accelerated tempo - a small but significant effect after primary infection, but a substantial enhancement of worm loss after reinfection. Auto-anti-IgE induction was not able to prevent the typical increase in IgE that accompanies an N. brasiliensis infection, nor did it alter the helminth-induced intestinal mastocytosis. When MMC degranulation was measured by assaying the serum levels of a specific rat mast protease (RMCP II) following secondary infection, the amount of RMCP II released was less in auto-anti-IgE-producing rats. These findings have implications for the importance of IgE, MMC and other cells of inflammation in an anti-parasitic response.

Langue d'origineEnglish
Pages (de-à)303-308
Nombre de pages6
JournalImmunology
Volume60
Numéro de publication2
Statut de publicationPublished - 1987
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

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