Adenosine and ATP receptors

Résultat de recherche: Chapter

66 Citations (Scopus)

Résumé

Adenosine and ATP, via P1 and P2 receptors respectively, can modulate pain transmission under physiological, inflammatory, and neuropathic pain conditions. Such influences reflect peripheral and central actions and effects on neurons as well as other cell types. In general, adenosine A1 receptors produce inhibitory effects on pain in a number of preclinical models and are a focus of attention. In humans, i.v. infusions of adenosine reduce some aspects of neuropathic pain and can reduce postoperative pain. For P2X receptors, there is a significant body of information indicating that inhibition of P2X3 receptors may be useful for relieving inflammatory and neuropathic pain. More recently, data have begun to emerge implicating P2X4, P2X7 and P2Y receptors in aspects of pain transmission. Both P1 and P2 receptors may represent novel targets for pain relief.

Langue d'origineEnglish
Titre de la publication principaleAnalgesia
ÉditeursChristoph Stein
Pages309-328
Nombre de pages20
DOI
Statut de publicationPublished - 2007

Séries de publication

PrénomHandbook of Experimental Pharmacology
Volume177
ISSN (imprimé)0171-2004
ISSN (électronique)1865-0325

ASJC Scopus Subject Areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

PubMed: MeSH publication types

  • Journal Article
  • Review

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