Admixture analysis of age at onset in bipolar disorder

Federica Tozzi; Mirko Manchia; Nicholas W. Galwey; Giovanni Severino; Maria Del Zompo; Richard Day; Keith Matthews; John Strauss; James L. Kennedy; Peter McGuffin; John B. Vincent; Anne Farmer; Pierandrea Muglia

doi:10.1016/j.psychres.2009.11.025

Admixture analysis of age at onset in bipolar disorder

Federica Tozzi, Mirko Manchia, Nicholas W. Galwey, Giovanni Severino, Maria Del Zompo, Richard Day, Keith Matthews, John Strauss, James L. Kennedy, Peter McGuffin, John B. Vincent, Anne Farmer, Pierandrea Muglia

Résultat de recherche: Article › examen par les pairs

44 Citations (Scopus)

Résumé

The aim of this study was to identify whether age at onset (AAO) identifies Bipolar Disorder (BD) subtypes, and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of AAO in 964 BD patients. Three distributions of AAO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of χ². Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on AAO distributions, and that early-onset is associated with higher rates of suicide attempts.

Langue d'origine	English
Pages (de-à)	27-32
Nombre de pages	6
Journal	Psychiatry Research
Volume	185
Numéro de publication	1-2
DOI	https://doi.org/10.1016/j.psychres.2009.11.025
Statut de publication	Published - janv. 30 2011
Publié à l'externe	Oui

Note bibliographique

Funding Information:
We would like to acknowledge the study participants, the academic investigators and the numerous scientists in Genetics Research and other R&D Divisions in GSK who helped to make this work possible. Funding for this study was provided by GlaxoSmithKline (Genetics, R&D) . GSK scientists were fully involved in the study design; in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the paper for publication.

Funding Information:
Keith Matthews has received research funding from GSK and Cyberonics Inc ; honoraria associated with lecturing and/or travel from Eli Lilly, Wyeth, Medtronic, and Bristol Myers Squibb; and has accepted consultancy fees and/or hospitality from Lundbeck and ANS Inc. Dr Day's employment was funded by GSK for the duration of data collection.

ASJC Scopus Subject Areas

Psychiatry and Mental health
Biological Psychiatry

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1016/j.psychres.2009.11.025

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abstract = "The aim of this study was to identify whether age at onset (AAO) identifies Bipolar Disorder (BD) subtypes, and to test whether the subgroups were confirmed by different clinical profiles. Admixture analysis was applied to determine a model that best fit the observed distribution of AAO in 964 BD patients. Three distributions of AAO were identified, and age means were 16.1 (S.D. 4.2), 25.4 (S.D. 2.5) and 32.2 (S.D. 9.5) years. A significant increased rate of suicide attempts, Bipolar I (BD I) caseness, and depressive onset was observed in the early-onset group when compared to those with later-onset by means of χ2. Findings from extant studies and our results are remarkably consistent in showing that BD can be subdivided into three groups based on AAO distributions, and that early-onset is associated with higher rates of suicide attempts.",

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AU - Farmer, Anne

AU - Muglia, Pierandrea

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Admixture analysis of age at onset in bipolar disorder

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

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