Adverse pregnancy outcomes are associated with an increased risk of postpartum prediabetes and diabetes in Chinese women with gestational diabetes

Shu Cao, Ninghua Li, Cuiping Zhang, Jinnan Liu, Hui Wang, Junhong Leng, Leishen Wang, Weiqin Li, Zhijie Yu, Gang Hu, Jing Li, Xilin Yang

Résultat de recherche: Articleexamen par les pairs

4 Citations (Scopus)

Résumé

Aims: To explore associations between adverse pregnancy outcomes and risk of postpartum diabetes and prediabetes among Chinese women with gestational diabetes mellitus (GDM). Methods: A total of 507 women with GDM who participated in a randomized controlled trial were successfully followed up at a median of 9.1 (interquartile range: 7.7–11.3) weeks after delivery and underwent a 75 g 2-h oral glucose tolerance test. GDM was diagnosed according to the International Association of Diabetes and Pregnancy Study Group's criteria. Postpartum diabetes and prediabetes were defined by the World Health Organization's. Generalized logit model was used to obtain odds ratios (OR) and 95% confidence interval (CI) of adverse pregnancy outcomes for postpartum diabetes, prediabetes and abnormal glucose regulation (AGR). Results: Of 507 women with GDM, 3.7% (19) women developed postpartum diabetes, 35.1% (178) women developed postpartum prediabetes. Preterm birth was associated with increased risk of postpartum prediabetes and AGR (adjusted OR: 3.24, 95%CI: 1.48–7.07 & 3.16, 1.46–6.85). Low birth weight was associated with the risk of postpartum prediabetes, diabetes and AGR (adjusted OR: 2.78, 95%CI: 1.13–6.86; 5.21, 1.13–24.02 & 2.99, 1.24–7.21). Conclusions: Preterm birth and low birth weight were predictive of postpartum prediabetes, diabetes or AGR in Chinese women with GDM.

Langue d'origineEnglish
Numéro d'article109817
JournalDiabetes Research and Clinical Practice
Volume186
DOI
Statut de publicationPublished - avr. 2022

Note bibliographique

Funding Information:
The authors thank all the health professionals of Tianjin Antenatal Network for their involvement and contributions to the study. X.Y. was the guarantor of this manuscript. This project was supported by the National Natural Science Foundation of China (Grant No: 81870549) and BRIDGES [Grant No: LT09-227]. BRIDGES was an International Diabetes Federation program supported by an educational grant from Lilly Diabetes.

Funding Information:
This project was supported by the National Natural Science Foundation of China (Grant No: 81870549) and BRIDGES [Grant No: LT09-227]. BRIDGES was an International Diabetes Federation program supported by an educational grant from Lilly Diabetes.

Publisher Copyright:
© 2022 Elsevier B.V.

ASJC Scopus Subject Areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

PubMed: MeSH publication types

  • Journal Article
  • Randomized Controlled Trial

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