Alkylamines: Novel lipid constituents in Deinococcus radiodurans

Robert Anderson

doi:10.1016/0005-2760(83)90016-4

Alkylamines: Novel lipid constituents in Deinococcus radiodurans

Robert Anderson

Résultat de recherche: Article › examen par les pairs

15 Citations (Scopus)

Résumé

The major plasma membrane phosphoglycolipid of Deinococcus radiodurans contains a series of alkylamines as structural constituents. Gas chromatographic-mass spectrometric analysis of the N-acetylated alkylamines isolated from this lipid demonstrated that the major alkylamines are saturated C-15, C-16, C-17 and monounsaturated C-16, C-17 and C-18 species.

Langue d'origine	English
Pages (de-à)	266-268
Nombre de pages	3
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	753
Numéro de publication	2
DOI	https://doi.org/10.1016/0005-2760(83)90016-4
Statut de publication	Published - sept. 20 1983
Publié à l'externe	Oui

Note bibliographique

Funding Information:
examples of bacterial sphingolipids occur in the Bacteriodes [8,9] although sphingolipids have also been detected in Bdellovibrio [lo], Flavobacteria [l l] and Mycopfasma [12]. Virtually all sphingosines characterized to date contain a 1,3-dihydroxy-2-amino-alkyl chain which may be linear, branched or unsaturated. The alkylamines of D. rudioduruns are, thus, structurally distinct from previously described sphingosines, primarily with respect to their lack of hydroxyl groups. The major phosphoglycolipid of D. radiodurans, from which the alkylamines were isolated, shows infrared evidence of an amide linkage (unpublished data). This suggestst hat, as is the case with sphingosine, the alkylamines of D. rudiodurans form more complex lipid structures via acylation of the amino group. Alkylamines apparently do not occur in the ‘free’ form in D. radiodurans, since analysis of total lipid extracts [2] failed to detect any free amino group-containing lipids. Further investigations will be necessary to determine whether such alkylamines may be considered functional analogs of sphingosine. The work described here was supported by a grant from the Medical Research Council of Canada. I thank Dr. M.W. Khalil and the MRC Group in Reproductive Biology for the use of the capillary gas chromatograph. I am also grateful to Mr. L. Marai for performing the coupled gas chromatography-mass spectrometry.

ASJC Scopus Subject Areas

Biophysics
Biochemistry
Endocrinology

Accès au document

10.1016/0005-2760(83)90016-4

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title = "Alkylamines: Novel lipid constituents in Deinococcus radiodurans",

abstract = "The major plasma membrane phosphoglycolipid of Deinococcus radiodurans contains a series of alkylamines as structural constituents. Gas chromatographic-mass spectrometric analysis of the N-acetylated alkylamines isolated from this lipid demonstrated that the major alkylamines are saturated C-15, C-16, C-17 and monounsaturated C-16, C-17 and C-18 species.",

author = "Robert Anderson",

note = "Funding Information: examples of bacterial sphingolipids occur in the Bacteriodes [8,9] although sphingolipids have also been detected in Bdellovibrio [lo], Flavobacteria [l l] and Mycopfasma [12]. Virtually all sphingosines characterized to date contain a 1,3-dihydroxy-2-amino-alkyl chain which may be linear, branched or unsaturated. The alkylamines of D. rudioduruns are, thus, structurally distinct from previously described sphingosines, primarily with respect to their lack of hydroxyl groups. The major phosphoglycolipid of D. radiodurans, from which the alkylamines were isolated, shows infrared evidence of an amide linkage (unpublished data). This suggestst hat, as is the case with sphingosine, the alkylamines of D. rudiodurans form more complex lipid structures via acylation of the amino group. Alkylamines apparently do not occur in the {\textquoteleft}free{\textquoteright} form in D. radiodurans, since analysis of total lipid extracts [2] failed to detect any free amino group-containing lipids. Further investigations will be necessary to determine whether such alkylamines may be considered functional analogs of sphingosine. The work described here was supported by a grant from the Medical Research Council of Canada. I thank Dr. M.W. Khalil and the MRC Group in Reproductive Biology for the use of the capillary gas chromatograph. I am also grateful to Mr. L. Marai for performing the coupled gas chromatography-mass spectrometry.",

year = "1983",

month = sep,

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doi = "10.1016/0005-2760(83)90016-4",

language = "English",

volume = "753",

pages = "266--268",

journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

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T2 - Novel lipid constituents in Deinococcus radiodurans

AU - Anderson, Robert

N1 - Funding Information: examples of bacterial sphingolipids occur in the Bacteriodes [8,9] although sphingolipids have also been detected in Bdellovibrio [lo], Flavobacteria [l l] and Mycopfasma [12]. Virtually all sphingosines characterized to date contain a 1,3-dihydroxy-2-amino-alkyl chain which may be linear, branched or unsaturated. The alkylamines of D. rudioduruns are, thus, structurally distinct from previously described sphingosines, primarily with respect to their lack of hydroxyl groups. The major phosphoglycolipid of D. radiodurans, from which the alkylamines were isolated, shows infrared evidence of an amide linkage (unpublished data). This suggestst hat, as is the case with sphingosine, the alkylamines of D. rudiodurans form more complex lipid structures via acylation of the amino group. Alkylamines apparently do not occur in the ‘free’ form in D. radiodurans, since analysis of total lipid extracts [2] failed to detect any free amino group-containing lipids. Further investigations will be necessary to determine whether such alkylamines may be considered functional analogs of sphingosine. The work described here was supported by a grant from the Medical Research Council of Canada. I thank Dr. M.W. Khalil and the MRC Group in Reproductive Biology for the use of the capillary gas chromatograph. I am also grateful to Mr. L. Marai for performing the coupled gas chromatography-mass spectrometry.

PY - 1983/9/20

Y1 - 1983/9/20

N2 - The major plasma membrane phosphoglycolipid of Deinococcus radiodurans contains a series of alkylamines as structural constituents. Gas chromatographic-mass spectrometric analysis of the N-acetylated alkylamines isolated from this lipid demonstrated that the major alkylamines are saturated C-15, C-16, C-17 and monounsaturated C-16, C-17 and C-18 species.

AB - The major plasma membrane phosphoglycolipid of Deinococcus radiodurans contains a series of alkylamines as structural constituents. Gas chromatographic-mass spectrometric analysis of the N-acetylated alkylamines isolated from this lipid demonstrated that the major alkylamines are saturated C-15, C-16, C-17 and monounsaturated C-16, C-17 and C-18 species.

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Alkylamines: Novel lipid constituents in Deinococcus radiodurans

Résumé

Note bibliographique

ASJC Scopus Subject Areas

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