An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence

Victor D. Martinez; Katey S.S. Enfield; David A. Rowbotham; Wan L. Lam

doi:10.1007/s10120-015-0487-y

An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence

Victor D. Martinez, Katey S.S. Enfield, David A. Rowbotham, Wan L. Lam

Résultat de recherche: Article › examen par les pairs

63 Citations (Scopus)

Résumé

The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature associated with recurrence-free survival. In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer.

Langue d'origine	English
Pages (de-à)	660-665
Nombre de pages	6
Journal	Gastric Cancer
Volume	19
Numéro de publication	2
DOI	https://doi.org/10.1007/s10120-015-0487-y
Statut de publication	Published - avr. 1 2016
Publié à l'externe	Oui

Note bibliographique

Funding Information:
K.S.S.E. is supported by a Charles Best Canada Graduate Scholarship from the Canadian Institutes of Health Research. Funding support for this work was through research grants to W.L.L. from the Canadian Institutes of Health Research, the Canadian Cancer Society, the Terry Fox Foundation (Canada) and the National Institutes of Heath (USA).

Funding Information:
K.S.S.E. is supported by a Charles Best Canada Graduate Scholarship from the Canadian Institutes of Health Research. Funding support for this work was through research grants to W.L.L. from the Canadian Institutes of Health Research, the Canadian Cancer Society, the Terry Fox FoundationÂ (Canada) and the National Institutes of Heath (USA).

Publisher Copyright:
© 2015, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.

ASJC Scopus Subject Areas

Oncology
Gastroenterology
Cancer Research

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1007/s10120-015-0487-y

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abstract = "The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature associated with recurrence-free survival. In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer.",

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AU - Rowbotham, David A.

AU - Lam, Wan L.

N1 - Funding Information: K.S.S.E. is supported by a Charles Best Canada Graduate Scholarship from the Canadian Institutes of Health Research. Funding support for this work was through research grants to W.L.L. from the Canadian Institutes of Health Research, the Canadian Cancer Society, the Terry Fox Foundation (Canada) and the National Institutes of Heath (USA). Funding Information: K.S.S.E. is supported by a Charles Best Canada Graduate Scholarship from the Canadian Institutes of Health Research. Funding support for this work was through research grants to W.L.L. from the Canadian Institutes of Health Research, the Canadian Cancer Society, the Terry Fox FoundationÂ (Canada) and the National Institutes of Heath (USA). Publisher Copyright: © 2015, The International Gastric Cancer Association and The Japanese Gastric Cancer Association.

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N2 - The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature associated with recurrence-free survival. In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer.

AB - The poor survival and recurrence rate in gastric adenocarcinoma highlights the need for cancer gene discovery. Towards this end, we globally assessed the expression of an emerging class of small non-coding RNAs, called PIWI-interacting RNAs (piRNAs). We analysed the transcriptomes of 358 non-malignant stomach tissue and gastric adenocarcinoma samples, and found that nearly half of the expressed piRNAs were overexpressed in tumours. Our gastric piRNA atlas showed that most piRNAs were embedded in protein-coding sequences rather than known piRNA clusters. Furthermore, we identified a three-piRNA signature associated with recurrence-free survival. In this proof-of-principle study, we demonstrate the potential clinical utility of piRNAs in gastric cancer.

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An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

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