Antibodies to polynucleotides: Distribution in human serums

D. Koffler; R. I. Carr; V. Agnello; T. Fiezi; H. G. Kunkel

doi:10.1126/science.166.3913.1648

Antibodies to polynucleotides: Distribution in human serums

D. Koffler, R. I. Carr, V. Agnello, T. Fiezi, H. G. Kunkel

Medicine

Medicine

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Résumé

Hemagglutination procedures were used to determine the distribution of antibodies to native DNA, single-stranded DNA, and doublestranded RNA. Antibodies to all three polynucleotides were found in a high percentage of the serums of patients. with systemic lupus erythematosus. Antibodies to native DNA occurred almost exclusively in serums of patients in the active stages of systemic lupus erythematosus, whereas antibodies to singlestranded DNA were observed in the serums of patients with several diseases and of some normal individuals.

Langue d'origine	English
Pages (de-à)	1648-1649
Nombre de pages	2
Journal	Science
Volume	166
Numéro de publication	3913
DOI	https://doi.org/10.1126/science.166.3913.1648
Statut de publication	Published - 1969

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10.1126/science.166.3913.1648

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abstract = "Hemagglutination procedures were used to determine the distribution of antibodies to native DNA, single-stranded DNA, and doublestranded RNA. Antibodies to all three polynucleotides were found in a high percentage of the serums of patients. with systemic lupus erythematosus. Antibodies to native DNA occurred almost exclusively in serums of patients in the active stages of systemic lupus erythematosus, whereas antibodies to singlestranded DNA were observed in the serums of patients with several diseases and of some normal individuals.",

author = "D. Koffler and Carr, {R. I.} and V. Agnello and T. Fiezi and Kunkel, {H. G.}",

year = "1969",

doi = "10.1126/science.166.3913.1648",

language = "English",

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T2 - Distribution in human serums

AU - Koffler, D.

AU - Carr, R. I.

AU - Agnello, V.

AU - Fiezi, T.

AU - Kunkel, H. G.

PY - 1969

Y1 - 1969

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AB - Hemagglutination procedures were used to determine the distribution of antibodies to native DNA, single-stranded DNA, and doublestranded RNA. Antibodies to all three polynucleotides were found in a high percentage of the serums of patients. with systemic lupus erythematosus. Antibodies to native DNA occurred almost exclusively in serums of patients in the active stages of systemic lupus erythematosus, whereas antibodies to singlestranded DNA were observed in the serums of patients with several diseases and of some normal individuals.

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Antibodies to polynucleotides: Distribution in human serums

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