Arsenic, asbestos and radon: Emerging players in lung tumorigenesis

Roland Hubaux; Daiana D. Becker-Santos; Katey Ss Enfield; Stephen Lam; Wan L. Lam; Victor D. Martinez

doi:10.1186/1476-069X-11-89

Arsenic, asbestos and radon: Emerging players in lung tumorigenesis

Roland Hubaux, Daiana D. Becker-Santos, Katey Ss Enfield, Stephen Lam, Wan L. Lam, Victor D. Martinez

Résultat de recherche: Review article › examen par les pairs

71 Citations (Scopus)

Résumé

The cause of lung cancer is generally attributed to tobacco smoking. However lung cancer in never smokers accounts for 10 to 25% of all lung cancer cases. Arsenic, asbestos and radon are three prominent non-tobacco carcinogens strongly associated with lung cancer. Exposure to these agents can lead to genetic and epigenetic alterations in tumor genomes, impacting genes and pathways involved in lung cancer development. Moreover, these agents not only exhibit unique mechanisms in causing genomic alterations, but also exert deleterious effects through common mechanisms, such as oxidative stress, commonly associated with carcinogenesis. This article provides a comprehensive review of arsenic, asbestos, and radon induced molecular mechanisms responsible for the generation of genetic and epigenetic alterations in lung cancer. A better understanding of the mode of action of these carcinogens will facilitate the prevention and management of lung cancer related to such environmental hazards.

Langue d'origine	English
Numéro d'article	89
Journal	Environmental Health: A Global Access Science Source
Volume	11
Numéro de publication	1
DOI	https://doi.org/10.1186/1476-069X-11-89
Statut de publication	Published - 2012
Publié à l'externe	Oui

Note bibliographique

Funding Information:
This work was supported by grants from the Canadian Institutes for Health Research (CIHR) (MOP-86731, MOP-77903, MOP-110949, MOP-230517), Canadian Cancer Society (CCS20485), NIH/NCI 1R01CA164783-01 and Department of Defence (CDMRP W81XWH-10-1-0634). D.D.B.S. is supported by a University of British Columbia 4YF scholarship, and K.S.S.E. by a Frederick Banting and Charles Best Canada Graduate Scholarship from CIHR.

ASJC Scopus Subject Areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1186/1476-069X-11-89

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abstract = "The cause of lung cancer is generally attributed to tobacco smoking. However lung cancer in never smokers accounts for 10 to 25% of all lung cancer cases. Arsenic, asbestos and radon are three prominent non-tobacco carcinogens strongly associated with lung cancer. Exposure to these agents can lead to genetic and epigenetic alterations in tumor genomes, impacting genes and pathways involved in lung cancer development. Moreover, these agents not only exhibit unique mechanisms in causing genomic alterations, but also exert deleterious effects through common mechanisms, such as oxidative stress, commonly associated with carcinogenesis. This article provides a comprehensive review of arsenic, asbestos, and radon induced molecular mechanisms responsible for the generation of genetic and epigenetic alterations in lung cancer. A better understanding of the mode of action of these carcinogens will facilitate the prevention and management of lung cancer related to such environmental hazards.",

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doi = "10.1186/1476-069X-11-89",

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AU - Lam, Stephen

AU - Lam, Wan L.

AU - Martinez, Victor D.

N1 - Funding Information: This work was supported by grants from the Canadian Institutes for Health Research (CIHR) (MOP-86731, MOP-77903, MOP-110949, MOP-230517), Canadian Cancer Society (CCS20485), NIH/NCI 1R01CA164783-01 and Department of Defence (CDMRP W81XWH-10-1-0634). D.D.B.S. is supported by a University of British Columbia 4YF scholarship, and K.S.S.E. by a Frederick Banting and Charles Best Canada Graduate Scholarship from CIHR.

PY - 2012

Y1 - 2012

N2 - The cause of lung cancer is generally attributed to tobacco smoking. However lung cancer in never smokers accounts for 10 to 25% of all lung cancer cases. Arsenic, asbestos and radon are three prominent non-tobacco carcinogens strongly associated with lung cancer. Exposure to these agents can lead to genetic and epigenetic alterations in tumor genomes, impacting genes and pathways involved in lung cancer development. Moreover, these agents not only exhibit unique mechanisms in causing genomic alterations, but also exert deleterious effects through common mechanisms, such as oxidative stress, commonly associated with carcinogenesis. This article provides a comprehensive review of arsenic, asbestos, and radon induced molecular mechanisms responsible for the generation of genetic and epigenetic alterations in lung cancer. A better understanding of the mode of action of these carcinogens will facilitate the prevention and management of lung cancer related to such environmental hazards.

AB - The cause of lung cancer is generally attributed to tobacco smoking. However lung cancer in never smokers accounts for 10 to 25% of all lung cancer cases. Arsenic, asbestos and radon are three prominent non-tobacco carcinogens strongly associated with lung cancer. Exposure to these agents can lead to genetic and epigenetic alterations in tumor genomes, impacting genes and pathways involved in lung cancer development. Moreover, these agents not only exhibit unique mechanisms in causing genomic alterations, but also exert deleterious effects through common mechanisms, such as oxidative stress, commonly associated with carcinogenesis. This article provides a comprehensive review of arsenic, asbestos, and radon induced molecular mechanisms responsible for the generation of genetic and epigenetic alterations in lung cancer. A better understanding of the mode of action of these carcinogens will facilitate the prevention and management of lung cancer related to such environmental hazards.

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Arsenic, asbestos and radon: Emerging players in lung tumorigenesis

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

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