Assessment of antiviral properties of peramivir against H7N9 avian influenza virus in an experimental mouse model

Amber Farooqui, Linxi Huang, Suwu Wu, Yingmu Cai, Min Su, Pengzhou Lin, Weihong Chen, Xibin Fang, Li Zhang, Yisu Liu, Tiansheng Zeng, Stephane G. Paquette, Adnan Khan, Alyson A. Kelvin, David J. Kelvina

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6 Citations (Scopus)

Résumé

The H7N9 influenza virus causes a severe form of disease in humans. Neuraminidase inhibitors, including oral oseltamivir and injectable peramivir, are the first choices of antiviral treatment for such cases; however, the clinical efficacy of these drugs is questionable. Animal experimental models are essential for understanding the viral replication kinetics under the selective pressure of antiviral agents. This study demonstrates the antiviral activity of peramivir in a mouse model of H7N9 avian influenza virus infection. The data show that repeated administration of peramivir at 30 mg/kg of body weight successfully eradicated the virus from the respiratory tract and extrapulmonary tissues during the acute response, prevented clinical signs of the disease, including neuropathy, and eventually protected mice against lethal H7N9 influenza virus infection. Early treatment with peramivir was found to be associated with better disease outcomes.

Langue d'origineEnglish
Pages (de-à)7255-7264
Nombre de pages10
JournalAntimicrobial Agents and Chemotherapy
Volume59
Numéro de publication12
DOI
Statut de publicationPublished - déc. 1 2015
Publié à l'externeOui

Note bibliographique

Publisher Copyright:
Copyright © 2015 Farooqui et al.

ASJC Scopus Subject Areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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