TY - JOUR
T1 - Association of health-related quality of life in childhood-onset systemic lupus erythematosus with ethnicity
T2 - Results from a multiethnic multicenter canadian cohort
AU - CANADIAN NETWORK FOR IMPROVED OUTCOMES IN SLE (CANIOS) 1000 FACES INVESTIGATORS
AU - Levy, Deborah M.
AU - Peschken, Christine A.
AU - Tucker, Lori B.
AU - Chédeville, Gaëlle
AU - Huber, Adam M.
AU - Pope, Janet E.
AU - Silverman, Earl D.
AU - Petty, Ross
AU - Cabral, David
AU - Houghton, Kristin
AU - Morishita, Kimberly
AU - Campillo, Sarah
AU - Duffy, Karen
AU - Scuccimarri, Rosie
AU - Lang, Bianca
AU - Ramsey, Suzanne
AU - Warner, Aleasha
AU - Ng, Lawrence
AU - Fortin, Paul
AU - Urowitz, Murray
AU - Gladman, Dafna
AU - Albert, Lori
AU - Carette, Simon
AU - Inman, Rob
AU - McKenzie, Tamara
AU - Clarke, Ann
AU - Pineau, Christian
AU - Bernatsky, Sasha
AU - Tobaly, Michele
AU - Santopietro, Tania
AU - Smith, C. Douglas
AU - Simpson, Sherri
AU - Smith, Katrin
AU - Zummer, Michel
AU - Ferland, Diane
AU - Arbillaga, Hector
AU - Wehlage, Annella
AU - Hudson, Marie
AU - Baron, Murray
AU - Berkson, Laeora
AU - Bernstein, Jessica
AU - Hanly, John
AU - Hewitt, Sara
AU - Ouimet, Janine
AU - Hitchon, Carol
AU - Craig, Andrea
AU - Moyen, Mellissa
N1 - Publisher Copyright:
© 2014, American College of Rheumatology.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Objective. To evaluate the influence of ethnicity on self-reported health-related quality of life (HRQOL) in the Canadian childhood-onset systemic lupus erythematosus (cSLE) population.Methods. Patients with cSLE at 4 pediatric centers were consecutively enrolled. Sociodemographics and multiple disease activity measures were collected. The Child Health Questionnaire (CHQ) was administered and analyzed by ethnicity.Results. We enrolled 213 cSLE patients, and complete data from 196 patients with the following ethnicities were analyzed: white (33%), Asian (32%), South Asian (16%), African American (11%), Latino/Hispanic (5%), and Aboriginal (4%). Compared to healthy children, cSLE patients rated their HRQOL significantly more poorly in 9 of 10 individual domains, and in 4 of 10 domains when compared to a cohort of juvenile arthritis patients. Within the cSLE cohort, CHQ scores were lower in 5 of 10 domains in white patients versus nonwhite ethnicities (P < 0.05 for each). Physical summary scores were lower for white patients compared to the other ethnicities aggregated together (mean ± SD 46.0 ± 11.9 versus 50.4 ± 10.1; P = 0.009); however, psychosocial summary scores were similar among the groups (mean ± SD 40.5 ± 14.6 versus 42.8 ± 12.7; P = 0.26). Disease activity measures, including the Systemic Lupus Erythematosus Disease Activity Index 2000, the Systemic Lupus Activity Measure, Revised, and physician global visual analog scale, were similar across ethnicities. However, patient-reported Systemic Lupus Erythematosus Activity Questionnaire symptom scores were greater in patients of white ethnicity compared to those of Asian ethnicity (mean ± SD 8.2 ± 5.8 versus 4.5 ± 4.7; P = 0.004).Conclusion. The self- and parent-reported health status of Canadian cSLE patients differed across ethnicities, with white patients reporting lower HRQOL despite similar and overall low disease activity.
AB - Objective. To evaluate the influence of ethnicity on self-reported health-related quality of life (HRQOL) in the Canadian childhood-onset systemic lupus erythematosus (cSLE) population.Methods. Patients with cSLE at 4 pediatric centers were consecutively enrolled. Sociodemographics and multiple disease activity measures were collected. The Child Health Questionnaire (CHQ) was administered and analyzed by ethnicity.Results. We enrolled 213 cSLE patients, and complete data from 196 patients with the following ethnicities were analyzed: white (33%), Asian (32%), South Asian (16%), African American (11%), Latino/Hispanic (5%), and Aboriginal (4%). Compared to healthy children, cSLE patients rated their HRQOL significantly more poorly in 9 of 10 individual domains, and in 4 of 10 domains when compared to a cohort of juvenile arthritis patients. Within the cSLE cohort, CHQ scores were lower in 5 of 10 domains in white patients versus nonwhite ethnicities (P < 0.05 for each). Physical summary scores were lower for white patients compared to the other ethnicities aggregated together (mean ± SD 46.0 ± 11.9 versus 50.4 ± 10.1; P = 0.009); however, psychosocial summary scores were similar among the groups (mean ± SD 40.5 ± 14.6 versus 42.8 ± 12.7; P = 0.26). Disease activity measures, including the Systemic Lupus Erythematosus Disease Activity Index 2000, the Systemic Lupus Activity Measure, Revised, and physician global visual analog scale, were similar across ethnicities. However, patient-reported Systemic Lupus Erythematosus Activity Questionnaire symptom scores were greater in patients of white ethnicity compared to those of Asian ethnicity (mean ± SD 8.2 ± 5.8 versus 4.5 ± 4.7; P = 0.004).Conclusion. The self- and parent-reported health status of Canadian cSLE patients differed across ethnicities, with white patients reporting lower HRQOL despite similar and overall low disease activity.
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U2 - 10.1002/acr.22363
DO - 10.1002/acr.22363
M3 - Article
C2 - 24821613
AN - SCOPUS:84912058854
SN - 2151-464X
VL - 66
SP - 1767
EP - 1774
JO - Arthritis Care and Research
JF - Arthritis Care and Research
IS - 12
ER -