Association of timing of birth with mortality among preterm infants born in Canada

on behalf of the Canadian Neonatal Network (CNN) and Canadian Preterm Birth Network (CPTBN) Investigators

doi:10.1038/s41372-021-01092-9

Association of timing of birth with mortality among preterm infants born in Canada

on behalf of the Canadian Neonatal Network (CNN) and Canadian Preterm Birth Network (CPTBN) Investigators

Résultat de recherche: Article › examen par les pairs

11 Citations (Scopus)

Résumé

Objective: To assess the association between time of birth and mortality among preterm infants. Study design: Population-based study of infants born 22–36 weeks gestation (GA) in Canada from 2010 to 2015 (n = 173 789). Multivariable logistic regression models assessed associations between timing of birth and mortality. Result: Among infants 22–27 weeks GA, evening birth was associated with higher mortality than daytime birth (adjusted odds ratio [AOR] 1.14, 95% CI 1.01–1.29). Among infants 28–32 weeks GA and 33–36 weeks GA, night birth was associated with lower mortality than daytime birth (AOR 0.75, 95% CI 0.59–0.95; AOR 0.78, 95% CI 0.62–0.99, respectively). Sensitivity analysis excluding infants with major congenital anomaly revealed that associations between hour of birth and mortality among infants born 28–32 and 33–36 weeks GA decreased or were not statistically significant. Conclusion: Higher mortality among extremely preterm infants during off-peak hours may suggest variations in available resources based on time of day.

Langue d'origine	English
Pages (de-à)	2597-2606
Nombre de pages	10
Journal	Journal of Perinatology
Volume	41
Numéro de publication	11
DOI	https://doi.org/10.1038/s41372-021-01092-9
Statut de publication	Published - nov. 2021
Publié à l'externe	Oui

Note bibliographique

Funding Information:
Funding This study was supported by a grant from the Canadian Institutes of Health Research (CIHR) funding the Canadian Preterm Birth Network (PBN 150642). Organizational support for the Canadian Neonatal Network and the Canadian Preterm Birth Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by a CIHR Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals. Prakesh Shah holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340). Marc Beltempo holds an Early Career Investigator Grant from the CIHR Institute of Human Development, Child and Youth Health (IHDCYH). The funding agencies had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

Accès au document

10.1038/s41372-021-01092-9

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title = "Association of timing of birth with mortality among preterm infants born in Canada",

abstract = "Objective: To assess the association between time of birth and mortality among preterm infants. Study design: Population-based study of infants born 22–36 weeks gestation (GA) in Canada from 2010 to 2015 (n = 173 789). Multivariable logistic regression models assessed associations between timing of birth and mortality. Result: Among infants 22–27 weeks GA, evening birth was associated with higher mortality than daytime birth (adjusted odds ratio [AOR] 1.14, 95% CI 1.01–1.29). Among infants 28–32 weeks GA and 33–36 weeks GA, night birth was associated with lower mortality than daytime birth (AOR 0.75, 95% CI 0.59–0.95; AOR 0.78, 95% CI 0.62–0.99, respectively). Sensitivity analysis excluding infants with major congenital anomaly revealed that associations between hour of birth and mortality among infants born 28–32 and 33–36 weeks GA decreased or were not statistically significant. Conclusion: Higher mortality among extremely preterm infants during off-peak hours may suggest variations in available resources based on time of day.",

author = "{on behalf of the Canadian Neonatal Network (CNN) and Canadian Preterm Birth Network (CPTBN) Investigators} and Angelo Rizzolo and Shah, {Prakesh S.} and Valerie Bertelle and Hala Makary and Ye, {Xiang Y.} and Abenhaim, {Haim A.} and Bruno Piedboeuf and Marc Beltempo and Haim Abenhaim and Jehier Afifi and Ruben Alvaro and James Andrews and Anthony Armson and Francois Audibert and Khalid Aziz and Marilyn Ballantyne and Jon Barrett and Marc Beltempo and Anick Berard and Valerie Bertelle and Lucie Blais and Alan Bocking and Jaya Bodani and Jason Burrows and Kimberly Butt and Roderick Canning and George Carson and Nils Chaillet and Sue Chandra and Paige Church and Zenon Cieslak and Kevin Coughlin and Joan Crane and Dianne Creighton and {Da Silva}, Orlando and Thierry Daboval and Leanne Dahlgren and Sibasis Daspal and {de Cabo}, Cecilia and Akhil Deshpandey and Kimberly Dow and Christine Drolet and Michael Dunn and {el Helou}, Salhab and Darine El-Chaar and Walid El-Naggar and Carlos Fajardo and Jonathan Foster and Robert Gagnon and Rob Gratton",

note = "Funding Information: Funding This study was supported by a grant from the Canadian Institutes of Health Research (CIHR) funding the Canadian Preterm Birth Network (PBN 150642). Organizational support for the Canadian Neonatal Network and the Canadian Preterm Birth Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by a CIHR Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals. Prakesh Shah holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340). Marc Beltempo holds an Early Career Investigator Grant from the CIHR Institute of Human Development, Child and Youth Health (IHDCYH). The funding agencies had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2021",

month = nov,

doi = "10.1038/s41372-021-01092-9",

language = "English",

volume = "41",

pages = "2597--2606",

journal = "Journal of Perinatology",

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T1 - Association of timing of birth with mortality among preterm infants born in Canada

AU - on behalf of the Canadian Neonatal Network (CNN) and Canadian Preterm Birth Network (CPTBN) Investigators

AU - Rizzolo, Angelo

AU - Shah, Prakesh S.

AU - Bertelle, Valerie

AU - Makary, Hala

AU - Ye, Xiang Y.

AU - Abenhaim, Haim A.

AU - Piedboeuf, Bruno

AU - Beltempo, Marc

AU - Abenhaim, Haim

AU - Afifi, Jehier

AU - Alvaro, Ruben

AU - Andrews, James

AU - Armson, Anthony

AU - Audibert, Francois

AU - Aziz, Khalid

AU - Ballantyne, Marilyn

AU - Barrett, Jon

AU - Beltempo, Marc

AU - Berard, Anick

AU - Bertelle, Valerie

AU - Blais, Lucie

AU - Bocking, Alan

AU - Bodani, Jaya

AU - Burrows, Jason

AU - Butt, Kimberly

AU - Canning, Roderick

AU - Carson, George

AU - Chaillet, Nils

AU - Chandra, Sue

AU - Church, Paige

AU - Cieslak, Zenon

AU - Coughlin, Kevin

AU - Crane, Joan

AU - Creighton, Dianne

AU - Da Silva, Orlando

AU - Daboval, Thierry

AU - Dahlgren, Leanne

AU - Daspal, Sibasis

AU - de Cabo, Cecilia

AU - Deshpandey, Akhil

AU - Dow, Kimberly

AU - Drolet, Christine

AU - Dunn, Michael

AU - el Helou, Salhab

AU - El-Chaar, Darine

AU - El-Naggar, Walid

AU - Fajardo, Carlos

AU - Foster, Jonathan

AU - Gagnon, Robert

AU - Gratton, Rob

N1 - Funding Information: Funding This study was supported by a grant from the Canadian Institutes of Health Research (CIHR) funding the Canadian Preterm Birth Network (PBN 150642). Organizational support for the Canadian Neonatal Network and the Canadian Preterm Birth Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by a CIHR Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals. Prakesh Shah holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340). Marc Beltempo holds an Early Career Investigator Grant from the CIHR Institute of Human Development, Child and Youth Health (IHDCYH). The funding agencies had no role in the design or conduct of the study; the collection, management, analysis, or interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2021/11

Y1 - 2021/11

N2 - Objective: To assess the association between time of birth and mortality among preterm infants. Study design: Population-based study of infants born 22–36 weeks gestation (GA) in Canada from 2010 to 2015 (n = 173 789). Multivariable logistic regression models assessed associations between timing of birth and mortality. Result: Among infants 22–27 weeks GA, evening birth was associated with higher mortality than daytime birth (adjusted odds ratio [AOR] 1.14, 95% CI 1.01–1.29). Among infants 28–32 weeks GA and 33–36 weeks GA, night birth was associated with lower mortality than daytime birth (AOR 0.75, 95% CI 0.59–0.95; AOR 0.78, 95% CI 0.62–0.99, respectively). Sensitivity analysis excluding infants with major congenital anomaly revealed that associations between hour of birth and mortality among infants born 28–32 and 33–36 weeks GA decreased or were not statistically significant. Conclusion: Higher mortality among extremely preterm infants during off-peak hours may suggest variations in available resources based on time of day.

AB - Objective: To assess the association between time of birth and mortality among preterm infants. Study design: Population-based study of infants born 22–36 weeks gestation (GA) in Canada from 2010 to 2015 (n = 173 789). Multivariable logistic regression models assessed associations between timing of birth and mortality. Result: Among infants 22–27 weeks GA, evening birth was associated with higher mortality than daytime birth (adjusted odds ratio [AOR] 1.14, 95% CI 1.01–1.29). Among infants 28–32 weeks GA and 33–36 weeks GA, night birth was associated with lower mortality than daytime birth (AOR 0.75, 95% CI 0.59–0.95; AOR 0.78, 95% CI 0.62–0.99, respectively). Sensitivity analysis excluding infants with major congenital anomaly revealed that associations between hour of birth and mortality among infants born 28–32 and 33–36 weeks GA decreased or were not statistically significant. Conclusion: Higher mortality among extremely preterm infants during off-peak hours may suggest variations in available resources based on time of day.

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U2 - 10.1038/s41372-021-01092-9

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SP - 2597

EP - 2606

JO - Journal of Perinatology

JF - Journal of Perinatology

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ER -

Association of timing of birth with mortality among preterm infants born in Canada

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

Empreinte numérique

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