Associations of cord blood leptin and adiponectin with children's cognitive abilities

Nan Li; Tye E. Arbuckle; Gina Muckle; Bruce P. Lanphear; Michel Boivin; Aimin Chen; Linda Dodds; William D. Fraser; Emmanuel Ouellet; Jean R. Séguin; Maria P. Velez; Kimberly Yolton; Joseph M. Braun

doi:10.1016/j.psyneuen.2018.10.021

Associations of cord blood leptin and adiponectin with children's cognitive abilities

Nan Li, Tye E. Arbuckle, Gina Muckle, Bruce P. Lanphear, Michel Boivin, Aimin Chen, Linda Dodds, William D. Fraser, Emmanuel Ouellet, Jean R. Séguin, Maria P. Velez, Kimberly Yolton, Joseph M. Braun

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13 Citations (Scopus)

Résumé

Background Adipocytokines may play a role in fetal programming of neurodevelopment. We aimed to investigate the associations between cord blood adipocytokine concentrations and children's intelligence test scores. Methods We used data from two ongoing pregnancy cohorts in North America: the Maternal-Infant Research on Environmental Chemicals (MIREC, n = 429) and Health Outcomes and Measures of the Environment (HOME, n = 183) Studies. Umbilical cord blood adipocytokine concentrations were measured using enzyme-linked immunosorbent assays. We assessed children's Intelligence Quotient (IQ) and its components using the Wechsler Preschool and Primary Scales of Intelligence-III or Wechsler Intelligence Scale for Children-IV. We used linear regression and linear mixed models to estimate associations between log₂-transformed adipocytokine concentrations and children's IQ after adjusting for sociodemographic, perinatal, and child factors. Results After adjusting for covariates, cord blood adiponectin was positively associated with children's full-scale IQ scores at age 3 years in the MIREC Study (β = 1.4, 95% confidence interval [CI]: 0.2, 2.5) and at ages 5 and 8 years in the HOME Study (β = 1.7, CI: −0.1, 3.5). Adiponectin was positively associated with performance IQ in both studies (MIREC: β = 2.0, CI: 0.7, 3.3; HOME: β = 2.2, CI: 0.5, 3.9). Adiponectin was positively associated with working memory composite scores at age 8 in the HOME Study (β = 3.1, CI: 1.0, 5.2). Leptin was not associated with children's IQ in either study. Conclusions Cord blood adiponectin was associated with higher full-scale and performance IQ and working memory composite scores in children. Future studies are needed to explore the mechanisms underlying these associations.

Langue d'origine	English
Pages (de-à)	257-264
Nombre de pages	8
Journal	Psychoneuroendocrinology
Volume	99
DOI	https://doi.org/10.1016/j.psyneuen.2018.10.021
Statut de publication	Published - janv. 2019
Publié à l'externe	Oui

Note bibliographique

Funding Information:
This work was supported by the National Institute of Environmental Health Sciences (grant numbers P01 ES011261 , R01 ES024381 , R01 ES025214 , R01 ES020349 , and R01 ES014575 ); Chemicals Management Plan of Health Canada ; the Canadian Institute of Health Research (grant number MOP-81285 ); the Ontario Ministry of the Environment ; and the Canadian Diabetes Association (grant number OG-2-11-33424-LD ).

Publisher Copyright:
© 2018 Elsevier Ltd

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1016/j.psyneuen.2018.10.021

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@article{bd9459ad52bf408ab6d74e42559df366,

title = "Associations of cord blood leptin and adiponectin with children's cognitive abilities",

abstract = "Background Adipocytokines may play a role in fetal programming of neurodevelopment. We aimed to investigate the associations between cord blood adipocytokine concentrations and children's intelligence test scores. Methods We used data from two ongoing pregnancy cohorts in North America: the Maternal-Infant Research on Environmental Chemicals (MIREC, n = 429) and Health Outcomes and Measures of the Environment (HOME, n = 183) Studies. Umbilical cord blood adipocytokine concentrations were measured using enzyme-linked immunosorbent assays. We assessed children's Intelligence Quotient (IQ) and its components using the Wechsler Preschool and Primary Scales of Intelligence-III or Wechsler Intelligence Scale for Children-IV. We used linear regression and linear mixed models to estimate associations between log2-transformed adipocytokine concentrations and children's IQ after adjusting for sociodemographic, perinatal, and child factors. Results After adjusting for covariates, cord blood adiponectin was positively associated with children's full-scale IQ scores at age 3 years in the MIREC Study (β = 1.4, 95% confidence interval [CI]: 0.2, 2.5) and at ages 5 and 8 years in the HOME Study (β = 1.7, CI: −0.1, 3.5). Adiponectin was positively associated with performance IQ in both studies (MIREC: β = 2.0, CI: 0.7, 3.3; HOME: β = 2.2, CI: 0.5, 3.9). Adiponectin was positively associated with working memory composite scores at age 8 in the HOME Study (β = 3.1, CI: 1.0, 5.2). Leptin was not associated with children's IQ in either study. Conclusions Cord blood adiponectin was associated with higher full-scale and performance IQ and working memory composite scores in children. Future studies are needed to explore the mechanisms underlying these associations.",

author = "Nan Li and Arbuckle, {Tye E.} and Gina Muckle and Lanphear, {Bruce P.} and Michel Boivin and Aimin Chen and Linda Dodds and Fraser, {William D.} and Emmanuel Ouellet and S{\'e}guin, {Jean R.} and Velez, {Maria P.} and Kimberly Yolton and Braun, {Joseph M.}",

note = "Funding Information: This work was supported by the National Institute of Environmental Health Sciences (grant numbers P01 ES011261 , R01 ES024381 , R01 ES025214 , R01 ES020349 , and R01 ES014575 ); Chemicals Management Plan of Health Canada ; the Canadian Institute of Health Research (grant number MOP-81285 ); the Ontario Ministry of the Environment ; and the Canadian Diabetes Association (grant number OG-2-11-33424-LD ). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

doi = "10.1016/j.psyneuen.2018.10.021",

language = "English",

volume = "99",

pages = "257--264",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Associations of cord blood leptin and adiponectin with children's cognitive abilities

AU - Li, Nan

AU - Arbuckle, Tye E.

AU - Muckle, Gina

AU - Lanphear, Bruce P.

AU - Boivin, Michel

AU - Chen, Aimin

AU - Dodds, Linda

AU - Fraser, William D.

AU - Ouellet, Emmanuel

AU - Séguin, Jean R.

AU - Velez, Maria P.

AU - Yolton, Kimberly

AU - Braun, Joseph M.

N1 - Funding Information: This work was supported by the National Institute of Environmental Health Sciences (grant numbers P01 ES011261 , R01 ES024381 , R01 ES025214 , R01 ES020349 , and R01 ES014575 ); Chemicals Management Plan of Health Canada ; the Canadian Institute of Health Research (grant number MOP-81285 ); the Ontario Ministry of the Environment ; and the Canadian Diabetes Association (grant number OG-2-11-33424-LD ). Publisher Copyright: © 2018 Elsevier Ltd

PY - 2019/1

Y1 - 2019/1

N2 - Background Adipocytokines may play a role in fetal programming of neurodevelopment. We aimed to investigate the associations between cord blood adipocytokine concentrations and children's intelligence test scores. Methods We used data from two ongoing pregnancy cohorts in North America: the Maternal-Infant Research on Environmental Chemicals (MIREC, n = 429) and Health Outcomes and Measures of the Environment (HOME, n = 183) Studies. Umbilical cord blood adipocytokine concentrations were measured using enzyme-linked immunosorbent assays. We assessed children's Intelligence Quotient (IQ) and its components using the Wechsler Preschool and Primary Scales of Intelligence-III or Wechsler Intelligence Scale for Children-IV. We used linear regression and linear mixed models to estimate associations between log2-transformed adipocytokine concentrations and children's IQ after adjusting for sociodemographic, perinatal, and child factors. Results After adjusting for covariates, cord blood adiponectin was positively associated with children's full-scale IQ scores at age 3 years in the MIREC Study (β = 1.4, 95% confidence interval [CI]: 0.2, 2.5) and at ages 5 and 8 years in the HOME Study (β = 1.7, CI: −0.1, 3.5). Adiponectin was positively associated with performance IQ in both studies (MIREC: β = 2.0, CI: 0.7, 3.3; HOME: β = 2.2, CI: 0.5, 3.9). Adiponectin was positively associated with working memory composite scores at age 8 in the HOME Study (β = 3.1, CI: 1.0, 5.2). Leptin was not associated with children's IQ in either study. Conclusions Cord blood adiponectin was associated with higher full-scale and performance IQ and working memory composite scores in children. Future studies are needed to explore the mechanisms underlying these associations.

AB - Background Adipocytokines may play a role in fetal programming of neurodevelopment. We aimed to investigate the associations between cord blood adipocytokine concentrations and children's intelligence test scores. Methods We used data from two ongoing pregnancy cohorts in North America: the Maternal-Infant Research on Environmental Chemicals (MIREC, n = 429) and Health Outcomes and Measures of the Environment (HOME, n = 183) Studies. Umbilical cord blood adipocytokine concentrations were measured using enzyme-linked immunosorbent assays. We assessed children's Intelligence Quotient (IQ) and its components using the Wechsler Preschool and Primary Scales of Intelligence-III or Wechsler Intelligence Scale for Children-IV. We used linear regression and linear mixed models to estimate associations between log2-transformed adipocytokine concentrations and children's IQ after adjusting for sociodemographic, perinatal, and child factors. Results After adjusting for covariates, cord blood adiponectin was positively associated with children's full-scale IQ scores at age 3 years in the MIREC Study (β = 1.4, 95% confidence interval [CI]: 0.2, 2.5) and at ages 5 and 8 years in the HOME Study (β = 1.7, CI: −0.1, 3.5). Adiponectin was positively associated with performance IQ in both studies (MIREC: β = 2.0, CI: 0.7, 3.3; HOME: β = 2.2, CI: 0.5, 3.9). Adiponectin was positively associated with working memory composite scores at age 8 in the HOME Study (β = 3.1, CI: 1.0, 5.2). Leptin was not associated with children's IQ in either study. Conclusions Cord blood adiponectin was associated with higher full-scale and performance IQ and working memory composite scores in children. Future studies are needed to explore the mechanisms underlying these associations.

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SN - 0306-4530

VL - 99

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JO - Psychoneuroendocrinology

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Associations of cord blood leptin and adiponectin with children's cognitive abilities

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

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